Autor segons l'article: Gonzalez Casanova I; Alonso-Gómez ÁM; Romaguera D; Toledo E; Fortuny E; López L; Ramallal R; Salas-Salvadó J; Tojal-Sierra L; Castañer O; Alonso A
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Resum: Atrial fibrillation has been associated with cognitive impairment. Whether subclinical abnormalities in atrial function and substrate predisposing to atrial fibrillation impact cognitive function has received limited attention. We tested associations of echocardiographic markers of atrial structure and function with cognitive function and decrease in 510 participants with obesity and metabolic syndrome (mean age SD of 64.4 [5.2] years in men and 66.5 [3.9] years in women). Left atrial (LA) markers (volume index, emptying fraction, strain, function index, and stiffness index) were estimated based on transthoracic echocardiography. General cognitive functioning (Mini-mental state examination), verbal ability (verbal fluency test), memory and attention (Digit Span Tests), and processing speed and executive function (Trail-Making Tests A and B) were assessed at baseline and at 2-year follow-up. Multiple linear regression was used to test associations of atrial markers (modeled in SD units) with baseline and 2-year changes in cognitive scores adjusted for demographic and health covariates. LA structure and function were not associated with cognitive function at baseline. Larger LA volume index (standardized β [95% confidence interval] −0.13 [−0.22 to −0.03]), lower peak longitudinal strain (−0.11 [−0.20 to −0.01]), and higher stiffness index (−0.18 [−0.28 to −0.08]) were associated with 2-year worsening in Trail-Making Test A. Strain measurements were also associated with a 2-year change in the Controlled Oral Word Association Test. In conclusion, overall, adverse markers of LA structure and function were associated with 2-year detrimental executive function-related cognitive changes in a sample of participants at high risk for cardiovascular disease, highlighting LA substrate as a potential risk factor for cognitive decrease and dementia.
Àrees temàtiques: Saúde coletiva Psicología Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Identificador de l'autor: 0000-0003-2700-7459
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: American Journal Of Cardiology. 183 122-128
Referència de l'ítem segons les normes APA: Gonzalez Casanova I; Alonso-Gómez ÁM; Romaguera D; Toledo E; Fortuny E; López L; Ramallal R; Salas-Salvadó J; Tojal-Sierra L; Castañer O; Alonso A (2022). Association of Left Atrial Structure and Function With Cognitive Function in Adults With Metabolic Syndrome. American Journal Of Cardiology, 183(), 122-128. DOI: 10.1016/j.amjcard.2022.08.006
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV