Autor segons l'article: Brezmes, Jesus; Llambrich, Maria; Cumeras, Raquel; Guma, Josep;
Departament: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/s de la URV: Brezmes Llecha, Jesús Jorge / Cumeras Olmeda, Raquel / Llambrich Rodriguez, Maria
Paraules clau: Urine Urea Threonine Pyruvic acid Prospective studies Precision medicine Nmr Metabolomics Lysine Humans Glucose Creatinine Colorectal neoplasms Colorectal cancer Carnitine Biomarkers Acetone Acetic acid Acetates
Resum: Metabolomics is a fundamental approach to discovering novel biomarkers and their potential use for precision medicine. When applied for population screening, NMR-based metabolomics can become a powerful clinical tool in precision oncology. Urine tests can be more widely accepted due to their intrinsic non-invasiveness. Our review provides the first exhaustive evaluation of NMR metabolomics for the determination of colorectal cancer (CRC) in urine. A specific search in PubMed, Web of Science, and Scopus was performed, and 10 studies met the required criteria. There were no restrictions on the query for study type, leading to not only colorectal cancer samples versus control comparisons, but also prospective studies of surgical effects. With this review, all compounds in the included studies were merged into a database. In doing so, we identified up to 100 compounds in urine samples, and 11 were found in at least three articles. Results were analyzed in three groups: case (CRC and adenomas)/control, pre-/post-surgery, and combining both groups. When combining the case-control and the pre-/post-surgery groups, up to twelve compounds were found to be relevant. Seven down-regulated metabolites in CRC were identified, creatinine, 4-hydroxybenzoic acid, acetone, carnitine, d-glucose, hippuric acid, l-lysine, l-threonine, and pyruvic acid, and three up-regulated compounds in CRC were identified, acetic acid, phenylacetylglutamine, and urea. The pathways and enrichment analysis returned only two pathways significantly expressed: the pyruvate metabolism and the glycolysis/gluconeogenesis pathway. In both cases, only the pyruvic acid (down-regulated in urine of CRC patients, with cancer cell proliferation effect in the tissue) and acetic acid (up-regulated in urine of CRC patients, with chemoprotective effect) were present.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: maria.llambrich@urv.cat raquel.cumeras@urv.cat maria.llambrich@urv.cat jesus.brezmes@urv.cat
Identificador de l'autor: 0000-0001-8418-0982 0000-0003-4663-4247 0000-0001-8418-0982 0000-0002-7704-8550
Data d'alta del registre: 2024-09-07
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 23 (19): 11171-
Referència de l'ítem segons les normes APA: Brezmes, Jesus; Llambrich, Maria; Cumeras, Raquel; Guma, Josep; (2022). Urine NMR Metabolomics for Precision Oncology in Colorectal Cancer. International Journal Of Molecular Sciences, 23(19), 11171-. DOI: 10.3390/ijms231911171
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2022
Tipus de publicació: Journal Publications
Repositori URV