Autor segons l'article: Andlujar, Isabel; Carmen Recio, M; Giner, Rosa M; Cienfuegos-Jovellanos, Elena; Laghi, Sara; Muguerza, Begona; Luis Rios, Jose
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Muguerza Marquínez, Maria Begoña
Paraules clau: Animal; Animals; Anti-inflammatories; Article; Bagg albino mouse; Cacao; Cell line; Chemistry; Cocoa; Colitis, ulcerative; Colon cells; Cyclooxygenase 2; Dextran sulfate sodium; Disease model; Disease models, animal; Diseases; Down regulation; Down-regulation; Drug effect; Epicatechin; Ex-vivo; Female; Flavonoid; Flavonoids; Genetics; Human; Humans; In-vitro; Inflammatory bowel disease; Inhibitory effect; Intestinal cells; Mammals; Metabolism; Mice; Mice, inbred balb c; Mouse; Mus; Nitric oxide; Oral administration; Phenol derivative; Phenolics; Phenols; Phosphorylation; Plant extract; Plant extracts; Polyphenols; Procyanidins; Sodium; Sodium sulfate; Stat1 protein; Stat1 transcription factor; Stat3 protein; Stat3 transcription factor; Theobroma cacao; Transcription factors; Ulcerative colitis
Resum: We studied a polyphenol-enriched cocoa extract (PCE) with epicatechin, procyanidin B2, catechin, and procyanidin B1 as the major phenolics for its anti-inflammatory properties against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. PCE reduced colon damage, with significant reductions in both the extent and the severity of the inflammation as well as in crypt damage and leukocyte infiltration in the mucosa. Analysis ex vivo showed clear decreases in the production of nitric oxide, cyclooxygenase-2, pSTAT-3, and pSTAT1?, with NF-B p65 production being slightly reduced. Moreover, NF-B activation was reduced in RAW 264.7 cells in vitro. In conclusion, the inhibitory effect of PCE on acute UC induced by DSS in mice was attenuated by oral administration of PCE obtained from cocoa. This effect is principally due to the inhibition of transcription factors STAT1 and STAT3 in intestinal cells, with NF-B inhibition also being implicated. © 2011 American Chemical Society.
Àrees temàtiques: Agricultural and biological sciences (all); Agricultural and biological sciences (miscellaneous); Agriculture; Agriculture, multidisciplinary; Astronomia / física; Biodiversidade; Biotecnología; Chemistry (all); Chemistry (miscellaneous); Chemistry, applied; Ciência da computação; Ciência de alimentos; Ciências agrárias i; Ciências ambientais; Ciências biológicas i; Ciências biológicas ii; Ciências biológicas iii; Educação; Engenharias ii; Engenharias iii; Engenharias iv; Ensino; Farmacia; Food science & technology; General agricultural and biological sciences; General chemistry; General medicine; Interdisciplinar; Materiais; Medicina i; Medicina ii; Medicina veterinaria; Nutrição; Odontología; Planejamento urbano e regional / demografia; Química; Saúde coletiva; Zootecnia / recursos pesqueiros
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: begona.muguerza@urv.cat
Data d'alta del registre: 2025-01-25
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://pubs.acs.org/doi/10.1021/jf2008925
Referència a l'article segons font original: Journal Of Agricultural And Food Chemistry. 59 (12): 6474-6483
Referència de l'ítem segons les normes APA: Andlujar, Isabel; Carmen Recio, M; Giner, Rosa M; Cienfuegos-Jovellanos, Elena; Laghi, Sara; Muguerza, Begona; Luis Rios, Jose (2011). Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells. Journal Of Agricultural And Food Chemistry, 59(12), 6474-6483. DOI: 10.1021/jf2008925
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1021/jf2008925
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2011
Tipus de publicació: Journal Publications
Repositori URV