Articles producció científica> Ciències Mèdiques Bàsiques

Influence of prior comorbidities and chronic medications use on the risk of COVID-19 in adults: a population-based cohort study in Tarragona, Spain

  • Dades identificatives

    Identificador: imarina:9289946
    Handle: https://hdl.handle.net/20.500.11797/imarina9289946
    Autors:
    Vila-Corcoles, AngelOchoa-Gondar, OlgaSatue-Gracia, Eva MTorrente-Fraga, CristinaGomez-Bertomeu, FredericVila-Rovira, AngelHospital-Guardiola, Immaculadade Diego-Cabanes, CintaBejarano-Romero, FerranBasora-Gallisa, Josep
    Resum:
    Objective To investigate possible relationships between pre-existing medical conditions (including common comorbidities and chronic medications) and risk for suffering COVID-19 disease in middle-aged and older adults. Design Population-based retrospective cohort study. Setting Twelve primary care centres (PCCs) in Tarragona (Spain). Participants 79 083 people (77 676 community-dwelling and 1407 nursing-home residents), who were all individuals aged >50 years affiliated to the 12 participating PCCs. Outcomes Baseline cohort characteristics (age, sex, vaccinations, comorbidities and chronic medications) were established at study start (1st. March 2020) and primary outcome was time to COVID-19 confirmed by PCR among cohort members throughout the epidemic period (from 1st. March 2020 to 23rd. May 2020). Risk for suffering COVID-19 was evaluated by Cox regression, estimating multivariable HRs adjusted for age, sex, comorbidities and medications use. Results During the study period, 2324 cohort members were PCR-tested, with 1944 negative and 380 positive results, which means an incidence of 480.5 PCR-confirmed COVID-19 cases per 100 000 persons-period. Assessing the total study cohort, only age (HR 1.02; 95% CI 1.01 to 1.03; p=0.002), nursing-home residence (HR 21.83; 95% CI 16.66 to 28.61; p<0.001) and receiving diuretics (HR 1.35; 95% CI 1.04 to 1.76; p=0.026) appeared independently associated with increased risk. Smoking (HR 0.62; 95% CI 0.41 to 0.93; p=0.022), ACE inhibitors (HR 0.68; 95% CI 0.47 to 0.99; p=0.046) and antihistamine (HR 0.47; 95% CI 0.22 to 1.01; p=0.052) were associated with a lower risk. Among community-dwelling individuals, cancer (HR 1.52; 95% CI 1.03 to 2.24; p=0.035), chronic respiratory disease (HR 1.82; 95% CI 1.08 to 3.07; p=0.025) and cardiac dis

  • Altres:

    Autor segons l'article: Vila-Corcoles, Angel; Ochoa-Gondar, Olga; Satue-Gracia, Eva M; Torrente-Fraga, Cristina; Gomez-Bertomeu, Frederic; Vila-Rovira, Angel; Hospital-Guardiola, Immaculada; de Diego-Cabanes, Cinta; Bejarano-Romero, Ferran; Basora-Gallisa, Josep
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Gomez Bertomeu, Frederic-Francesc
    Paraules clau: Spain Risk factors Retrospective studies Public health Proportional hazards models Primary care Pharmaceutical preparations Nursing homes Middle aged Male Influenza vaccines Humans Heart diseases Female Epidemiology Covid-19 Comorbidity Angiotensin-converting enzyme inhibitors Aged, 80 and over Aged
    Resum: Objective To investigate possible relationships between pre-existing medical conditions (including common comorbidities and chronic medications) and risk for suffering COVID-19 disease in middle-aged and older adults. Design Population-based retrospective cohort study. Setting Twelve primary care centres (PCCs) in Tarragona (Spain). Participants 79 083 people (77 676 community-dwelling and 1407 nursing-home residents), who were all individuals aged >50 years affiliated to the 12 participating PCCs. Outcomes Baseline cohort characteristics (age, sex, vaccinations, comorbidities and chronic medications) were established at study start (1st. March 2020) and primary outcome was time to COVID-19 confirmed by PCR among cohort members throughout the epidemic period (from 1st. March 2020 to 23rd. May 2020). Risk for suffering COVID-19 was evaluated by Cox regression, estimating multivariable HRs adjusted for age, sex, comorbidities and medications use. Results During the study period, 2324 cohort members were PCR-tested, with 1944 negative and 380 positive results, which means an incidence of 480.5 PCR-confirmed COVID-19 cases per 100 000 persons-period. Assessing the total study cohort, only age (HR 1.02; 95% CI 1.01 to 1.03; p=0.002), nursing-home residence (HR 21.83; 95% CI 16.66 to 28.61; p<0.001) and receiving diuretics (HR 1.35; 95% CI 1.04 to 1.76; p=0.026) appeared independently associated with increased risk. Smoking (HR 0.62; 95% CI 0.41 to 0.93; p=0.022), ACE inhibitors (HR 0.68; 95% CI 0.47 to 0.99; p=0.046) and antihistamine (HR 0.47; 95% CI 0.22 to 1.01; p=0.052) were associated with a lower risk. Among community-dwelling individuals, cancer (HR 1.52; 95% CI 1.03 to 2.24; p=0.035), chronic respiratory disease (HR 1.82; 95% CI 1.08 to 3.07; p=0.025) and cardiac disease (HR 1.53; 95% CI 1.06 to 2.19; p=0.021) emerged to be also associated with an increased risk. Receiving ACE inhibitors (HR 0.66; 95% CI 0.44 to 0.99; p=0.046) and influenza vaccination (HR 0.63; 95% CI 0.44 to 0.91; p=0.012) was associated with decreased risk. Conclusion Age, nursing-home residence and multiple comorbidities appear predisposing for COVID-19. Conversely, receiving ACE inhibitors, antihistamine and influenza vaccination could be protective, which should be closely investigated in further studies specifically focused on these concerns.
    Àrees temàtiques: Saúde coletiva Psicología Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência da computação Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: frederic-francesc.gomez@urv.cat
    Identificador de l'autor: 0000-0002-8039-2889
    Data d'alta del registre: 2025-02-19
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Bmj Open. 10 (12): e041577-
    Referència de l'ítem segons les normes APA: Vila-Corcoles, Angel; Ochoa-Gondar, Olga; Satue-Gracia, Eva M; Torrente-Fraga, Cristina; Gomez-Bertomeu, Frederic; Vila-Rovira, Angel; Hospital-Guardi (2020). Influence of prior comorbidities and chronic medications use on the risk of COVID-19 in adults: a population-based cohort study in Tarragona, Spain. Bmj Open, 10(12), e041577-. DOI: 10.1136/bmjopen-2020-041577
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Medicine (Miscellaneous),Medicine, General & Internal
    Spain
    Risk factors
    Retrospective studies
    Public health
    Proportional hazards models
    Primary care
    Pharmaceutical preparations
    Nursing homes
    Middle aged
    Male
    Influenza vaccines
    Humans
    Heart diseases
    Female
    Epidemiology
    Covid-19
    Comorbidity
    Angiotensin-converting enzyme inhibitors
    Aged, 80 and over
    Aged
    Saúde coletiva
    Psicología
    Odontología
    Nutrição
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência da computação
    Biotecnología

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