Articles producció científica> Bioquímica i Biotecnologia

Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial

  • Dades identificatives

    Identificador: imarina:9295573
  • Autors:

    Toledo, E
    Wittenbecher, C
    Razquin, C
    Ruiz-Canela, M
    Clish, CB
    Liang, LM
    Alonso, A
    Hernández-Alonso, P
    Becerra-Tomás, N
    Arós-Borau, F
    Corella, D
    Ros, E
    Estruch, R
    García-Rodríguez, A
    Fitó, M
    Lapetra, J
    Fiol, M
    Alonso-Gomez, AM
    Serra-Majem, L
    Deik, A
    Salas-Salvadó, J
    Hu, FB
    Martínez-González, MA
  • Altres:

    Autor segons l'article: Toledo, E; Wittenbecher, C; Razquin, C; Ruiz-Canela, M; Clish, CB; Liang, LM; Alonso, A; Hernández-Alonso, P; Becerra-Tomás, N; Arós-Borau, F; Corella, D; Ros, E; Estruch, R; García-Rodríguez, A; Fitó, M; Lapetra, J; Fiol, M; Alonso-Gomez, AM; Serra-Majem, L; Deik, A; Salas-Salvadó, J; Hu, FB; Martínez-González, MA
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Becerra Tomás, Nerea / Salas Salvadó, Jorge
    Paraules clau: Nested case–control study Metabolomics Lipidomics Dietary intervention Atrial fibrillation nested case-control study metabolomics lipidomics dietary intervention
    Resum: The potential role of the lipidome in atrial fibrillation (AF) development is still widely unknown. We aimed to assess the association between lipidome profiles of the Prevención con Dieta Mediterránea (PREDIMED) trial participants and incidence of AF. We conducted a nested case–control study (512 incident centrally adjudicated AF cases and 735 controls matched by age, sex, and center). Baseline plasma lipids were profiled using a Nexera X2 U-HPLC system coupled to an Exactive Plus orbitrap mass spectrometer. We estimated the association between 216 individual lipids and AF using multivariable conditional logistic regression and adjusted the p values for multiple testing. We also examined the joint association of lipid clusters with AF incidence. Hitherto, we estimated the lipidomics network, used machine learning to select important network-clusters and AF-predictive lipid patterns, and summarized the joint association of these lipid patterns weighted scores. Finally, we addressed the possible interaction by the randomized dietary intervention. Forty-one individual lipids were associated with AF at the nominal level (p < 0.05), but no longer after adjustment for multiple-testing. However, the network-based score identified with a robust data-driven lipid network showed a multivariable-adjusted ORper+1SD of 1.32 (95% confidence interval: 1.16–1.51; p < 0.001). The score included PC plasmalogens and PE plasmalogens, palmitoyl-EA, cholesterol, CE 16:0, PC 36:4;O, and TG 53:3. No interaction with the dietary intervention was found. A multilipid score, primarily made up of plasmalogens, was associated with an increased risk of AF. Future studies are needed to get further insights into the lipidome role on AF. Current Controlled Trials number, ISRCTN35739639.
    Àrees temàtiques: Physiology Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biochemistry & molecular biology Biochemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: nerea.becerra@urv.cat jordi.salas@urv.cat
    Identificador de l'autor: 0000-0002-4429-6507 0000-0003-2700-7459
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://link.springer.com/article/10.1007/s13105-023-00958-0
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Journal Of Physiology And Biochemistry. 79 (2): 355-364
    Referència de l'ítem segons les normes APA: Toledo, E; Wittenbecher, C; Razquin, C; Ruiz-Canela, M; Clish, CB; Liang, LM; Alonso, A; Hernández-Alonso, P; Becerra-Tomás, N; Arós-Borau, F; Corella (2023). Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial. Journal Of Physiology And Biochemistry, 79(2), 355-364. DOI: 10.1007/s13105-023-00958-0
    DOI de l'article: 10.1007/s13105-023-00958-0
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry,Biochemistry & Molecular Biology,Medicine (Miscellaneous),Physiology
    Nested case–control study
    Metabolomics
    Lipidomics
    Dietary intervention
    Atrial fibrillation
    nested case-control study
    metabolomics
    lipidomics
    dietary intervention
    Physiology
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Enfermagem
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biochemistry & molecular biology
    Biochemistry
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