Autor segons l'article: Auguet, Teresa; Bertran, Laia; Capellades, Jordi; Abello, Sonia; Aguilar, Carmen; Sabench, Fatima; del Castillo, Daniel; Correig, Xavier; Yanes, Oscar; Richart, Cristobal
Departament: Medicina i Cirurgia Enginyeria Electrònica, Elèctrica i Automàtica
Autor/s de la URV: ABELLÓ CROS, SÒNIA / Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Correig Blanchar, Francesc Xavier / Del Castillo Déjardin, Daniel / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima / Yanes Torrado, Óscar
Paraules clau: Obesity, morbid Obesity Metabolomics Metabolome Metabolites Mass spectrometry Humans Female Fatty-acid Diabetes mellitus, type 2 Diabetes Chromatography, liquid Biomarkers Bile acids and salts signature secretion profiles plasma metabolomics metabolites metabolism insulin-resistance diabetes biomarkers bile-acids amino-acids
Resum: Obesity is a chronic and complex disease, with an increasing incidence worldwide that is associated with metabolic disorders such as type 2 diabetes mellitus (T2DM). Thus, it is important to determine the differences between metabolically healthy obese individuals and those with metabolic disorders. The aim of this study was to perform an untargeted metabolomics assay in women with morbid obesity (MO) compared to a normal weight group, and to differentiate the metabolome of these women with MO who present with T2DM. We carried out a liquid chromatography-mass spectrometry-based untargeted metabolomics assay using serum samples of 209 Caucasian women: 73 with normal weight and 136 with MO, of which 71 had T2DM. First, we found increased levels of choline and acylglycerols and lower levels of bile acids, steroids, ceramides, glycosphingolipids, lysophosphatidylcholines, and lysophosphatidylethanolamines in MO women than in the control group. Then, in MO women with T2DM, we found increased levels of glutamate, propionyl-carnitine, bile acids, ceramides, lysophosphatidylcholine 14:0, phosphatidylinositols and phosphoethanolamines, and lower levels of Phe-Ile/Leu. Thus, we found metabolites with opposite trends of concentration in the two metabolomic analyses. These metabolites could be considered possible new factors of study in the pathogenesis of MO and associated T2DM in women.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: oscar.yanes@urv.cat danieldel.castillo@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat xavier.correig@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Identificador de l'autor: 0000-0003-3695-7157 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-6902-3054 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Data d'alta del registre: 2024-09-28
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/24/9/7761
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 24 (9): 7761-
Referència de l'ítem segons les normes APA: Auguet, Teresa; Bertran, Laia; Capellades, Jordi; Abello, Sonia; Aguilar, Carmen; Sabench, Fatima; del Castillo, Daniel; Correig, Xavier; Yanes, Oscar (2023). LC/MS-Based Untargeted Metabolomics Analysis in Women with Morbid Obesity and Associated Type 2 Diabetes Mellitus. International Journal Of Molecular Sciences, 24(9), 7761-. DOI: 10.3390/ijms24097761
DOI de l'article: 10.3390/ijms24097761
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications