Serum Activin A and Follistatin Levels in Gestational Diabetes and the Association of the Activin A-Follistatin System with Anthropometric Parameters in Offspring

Autor segons l'article: Naef, Silvia; Escote, Xavier; Ballesteros, Monica; Elena Yanez, Rosa; Simon-Muela, Inmaculada; Gil, Pilar; Albaiges, Gerard; Vendrell, Joan; Megia, Ana

Departament: Medicina i Cirurgia

Autor/s de la URV: Albaigès Baiget, Gerard / Ballesteros Pérez, Monica / Escote Miro, Xavier / Gil Romero, Pilar / Megía Colet, Ana / Simón Muela, María Inmaculada / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José

Paraules clau: Fetal-growth; Glucose; Homeostasis; Mellitus; Myostatin; Neonatal body-composition; Pregnancies; Proliferation; Secretion; Ultrasound

Resum: Context: The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth.Objective: To analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and their relationship with glucose metabolism in pregnant women and their influence on fetal growth and neonatal adiposity.Design and methods: A prospective cohort was studied comprising 207 pregnant women, 129 with normal glucose tolerance (NGT) and 78 with gestational diabetes mellitus (GDM) and their offspring. Activin A, follistatin and FSTL3 levels were measured in maternal serum collected in the early third trimester of pregnancy. Serial fetal ultrasounds were performed during the third trimester to evaluate fetal growth. Neonatal anthropometry was measured to assess neonatal adiposity.Results: Serum follistatin levels were significantly lower in GDM than in NGT pregnant women (8.21 +/- 2.32 ng/mL vs 9.22 +/- 3.41, P = 0.012) whereas serum FSTL3 and activin A levels were comparable between the two groups. Serum follistatin concentrations were negatively correlated with HOMA-IR and positively with ultrasound growth parameters such as fractional thigh volume estimation in the middle of the third trimester and percent fat mass at birth. Also, in the stepwise multiple linear regression analysis serum follistatin levels were negatively associated with HOMA-IR (beta = 20.199, P = 0.008) and the diagnosis of gestational diabetes (beta = -0.138, P = 0.049). Likewise, fractional thigh volume estimation in the middle of third trimester and percent fat mass at birth were positively determined by serum follistatin levels (beta = 0.214, P = 0.005 and beta = 0.231, P = 0.002, respectively).Conclusions: Circulating follistatin levels are reduced in GDM compared with NGT pregnant women and they are positively associated with fetal growth and neonatal adiposity. These data suggest a role of the Activin-Follistatin system in maternal and fetal metabolism during pregnancy.

Grup de recerca: SIGNAMET

Àrees temàtiques: Administração pública e de empresas, ciências contábeis e turismo; Administração, ciências contábeis e turismo; Agricultural and biological sciences (miscellaneous); Anthropology; Antropologia / arqueologia; Archaeology; Arquitetura, urbanismo e design; Astronomia / física; Biochemistry, genetics and molecular biology (miscellaneous); Biodiversidade; Biology; Biotecnología; Ciência da computação; Ciência de alimentos; Ciência política e relações internacionais; Ciências agrárias i; Ciências ambientais; Ciências biológicas i; Ciências biológicas ii; Ciências biológicas iii; Ciências sociais aplicadas i; Comunicação e informação; Demography; Direito; Economia; Educação; Educação física; Enfermagem; Engenharias i; Engenharias ii; Engenharias iii; Engenharias iv; Ensino; Environmental studies; Farmacia; General agricultural and biological sciences; General biochemistry,genetics and molecular biology; General medicine; Geociências; Geografía; Historia; History & philosophy of science; Human geography and urban studies; Interdisciplinar; Interdisciplinary research in the social sciences; Letras / linguística; Linguística e literatura; Matemática / probabilidade e estatística; Materiais; Medicina i; Medicina ii; Medicina iii; Medicina veterinaria; Medicine (miscellaneous); Multidisciplinary; Multidisciplinary sciences; Nutrição; Odontología; Planejamento urbano e regional / demografia; Psicología; Psychology; Química; Saúde coletiva; Serviço social; Sociología; Sociology; Zootecnia / recursos pesqueiros

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: jvortega@iispv.cat; ana.megia@urv.cat; monica.ballesteros@urv.cat; xavier.escote@urv.cat; pilar.gil@urv.cat

Data d'alta del registre: 2025-02-08

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Referència a l'article segons font original: Plos One. 9 (4): e92175-

Referència de l'ítem segons les normes APA: Naef, Silvia; Escote, Xavier; Ballesteros, Monica; Elena Yanez, Rosa; Simon-Muela, Inmaculada; Gil, Pilar; Albaiges, Gerard; Vendrell, Joan; Megia, An (2014). Serum Activin A and Follistatin Levels in Gestational Diabetes and the Association of the Activin A-Follistatin System with Anthropometric Parameters in Offspring. Plos One, 9(4), e92175-. DOI: 10.1371/journal.pone.0092175

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

DOI de l'article: 10.1371/journal.pone.0092175

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2014

Tipus de publicació: Journal Publications