In Vitro Activity and In Vivo Efficacy of Anidulafungin in Murine Infections by Aspergillus flavus

Identificador:  imarina:9298544

Handle: https://hdl.handle.net/20.500.11797/imarina9298544

Autors:  Calvo, E; Pastor, FJ; Mayayo, E; Salas, V; Guarro, J

Resum:
Anidulafungin (AFG) showed high activity against 27 strains of Aspergillus flavus by use of broth microdilution and disk diffusion methods. This drug was effective in vivo in a murine model of disseminated infection with five isolates tested. AFG was able to prolong survival and reduce tissue burden of infected mice but not able to reduce galactomannan serum concentrations. The AFG serum levels were above the corresponding minimum effective concentrations (MEC) for all of the strains tested.