Autor segons l'article: Miguens-Gomez, Alba; Sierra-Cruz, Marta; Blay, M Teresa; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Terra, Ximena; Pinent, Montserrat; Ardevol, Anna
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
Paraules clau: Rats; Procyanidins; Proanthocyanidins; Intestine; Grape seed extract; Glucagon-like peptide 1; Glp-1; Female; Fatty acids, volatile; Colon; Cholecystokinin; Cck; Animals; Aging
Resum: The impact that healthy aging can have on society has raised great interest in understanding aging mechanisms. However, the effects this biological process may have on the gastrointestinal tract (GIT) have not yet been fully described. Results in relation to changes observed in the enteroendocrine system along the GIT are controversial. Grape seed proanthocyanidin extracts (GSPE) have been shown to protect against several pathologies associated with aging. Based on previous results, we hypothesized that a GSPE pre-treatment could prevent the aging processes that affect the enteroendocrine system. To test this hypothesis, we treated 21-month-old female rats with GSPE for 10 days. Eleven weeks after the treatment, we analyzed the effects of GSPE by comparing these aged animals with young animals. Aging induced a greater endocrine response to stimulation in the upper GIT segments (cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1)), a decrease in the mRNA abundance of GLP-1, peptide YY (PYY) and chromogranin A (ChgA) in the colon, and an increase in colonic butyrate. GSPE-treated rats were protected against a decrease in enterohormone expression in the colon. This effect is not directly related to the abundance of microbiome or short-chain fatty acids (SCFA) at this location. GSPE may therefore be effective in preventing a decrease in the colonic abundance of enterohormone expression induced by aging.
Àrees temàtiques: Zootecnia / recursos pesqueiros; Spectroscopy; Saúde coletiva; Química; Psicología; Physical and theoretical chemistry; Organic chemistry; Odontología; Nutrição; Molecular biology; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Inorganic chemistry; Geociências; Farmacia; Engenharias iv; Engenharias ii; Engenharias i; Educação física; Computer science applications; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, multidisciplinary; Catalysis; Biotecnología; Biodiversidade; Biochemistry & molecular biology; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: alba.miguens@urv.cat; marta.sierra@estudiants.urv.cat; anna.ardevol@urv.cat; ximena.terra@urv.cat; mteresa.blay@urv.cat; esther.rodriguez@urv.cat; montserrat.pinent@urv.cat; raul.beltran@urv.cat
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/24/9/7807
Referència a l'article segons font original: International Journal Of Molecular Sciences. 24 (9): 7807-
Referència de l'ítem segons les normes APA: Miguens-Gomez, Alba; Sierra-Cruz, Marta; Blay, M Teresa; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Terra, Ximena; Pinent, Montserrat; Ardevol, A (2023). GSPE Pre-Treatment Exerts Long-Lasting Preventive Effects against Aging-Induced Changes in the Colonic Enterohormone Profile of Female Rats. International Journal Of Molecular Sciences, 24(9), 7807-. DOI: 10.3390/ijms24097807
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3390/ijms24097807
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV