Articles producció científica> Química Analítica i Química Orgànica

Temperature-Responsive Lactic Acid-Based Nanoparticles by RAFT-Mediated Polymerization-Induced Self-Assembly in Water

  • Dades identificatives

    Identificador: imarina:9325761
    Autors:
    Woods, SETinkler, JDBensabeh, NPalà, MMartin, SJMartin-Fabiani, ILligadas, GHatton, FL
    Resum:
    This work demonstrates for the first-time biobased, temperature-responsive diblock copolymer nanoparticles synthesized by reversible addition-fragmentation chain-transfer (RAFT) aqueous emulsion polymerization-induced self-assembly (PISA). Here, monomers derived from green solvents of the lactic acid portfolio, N,N-dimethyl lactamide acrylate (DMLA) and ethyl lactate acrylate (ELA), were used. First, DMLA was polymerized by RAFT aqueous solution polymerization to produce a hydrophilic PDMLA macromolecular chain transfer agent (macro-CTA), which was chain extended with ELA in water to form amphiphilic PDMLA-b-PELA diblock copolymer nanoparticles by RAFT aqueous emulsion polymerization. PDMLAx homopolymers were synthesized targeting degrees of polymerization, DPx from 25 to 400, with relatively narrow molecular weight dispersities (Đ < 1.30). The PDMLA64-b-PELAy diblock copolymers (DPy = 10-400) achieved dispersities, Đ, between 1.18 and 1.54 with two distinct glass transition temperatures (Tg) identified by differential scanning calorimetry (DSC). Tg(1) (7.4 to 15.7 °C) representative of PELA and Tg(2) (69.1 to 79.7 °C) of PDMLA. Dynamic light scattering (DLS) studies gave particle z-average diameters between 11 and 74 nm (PDI = 0.04 to 0.20). Atomic force microscopy (AFM) showed evidence of spherical particles when dispersions were dried at ∼5 °C and film formation when dried at room temperature. Many of these polymers exhibited a reversible lower critical solution temperature (LCST) in water with a concomitant increase in z-average diameter for the PDMLA-b-PELA diblock copolymer nanoparticles.
  • Altres:

    Autor segons l'article: Woods, SE; Tinkler, JD; Bensabeh, N; Palà, M; Martin, SJ; Martin-Fabiani, I; Lligadas, G; Hatton, FL
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: Bensabeh, Nabil / Lligadas Puig, Gerard / PALÀ SÁNCHEZ, MARC
    Paraules clau: Thermoresponsive Temperature-responsive Raft Pisa Initio emulsion polymerization Green solvent Emulsion polymerization Biobased polymers Amphiphilic copolymers worms transition-temperatures thermoresponsive temperature-responsive radical polymerization pisa monomer green solvent fragmentation chain transfer ethyl lactate emulsion polymerization copolymer nano-objects biobasedpolymers amphiphilic copolymers acrylate
    Resum: This work demonstrates for the first-time biobased, temperature-responsive diblock copolymer nanoparticles synthesized by reversible addition-fragmentation chain-transfer (RAFT) aqueous emulsion polymerization-induced self-assembly (PISA). Here, monomers derived from green solvents of the lactic acid portfolio, N,N-dimethyl lactamide acrylate (DMLA) and ethyl lactate acrylate (ELA), were used. First, DMLA was polymerized by RAFT aqueous solution polymerization to produce a hydrophilic PDMLA macromolecular chain transfer agent (macro-CTA), which was chain extended with ELA in water to form amphiphilic PDMLA-b-PELA diblock copolymer nanoparticles by RAFT aqueous emulsion polymerization. PDMLAx homopolymers were synthesized targeting degrees of polymerization, DPx from 25 to 400, with relatively narrow molecular weight dispersities (Đ < 1.30). The PDMLA64-b-PELAy diblock copolymers (DPy = 10-400) achieved dispersities, Đ, between 1.18 and 1.54 with two distinct glass transition temperatures (Tg) identified by differential scanning calorimetry (DSC). Tg(1) (7.4 to 15.7 °C) representative of PELA and Tg(2) (69.1 to 79.7 °C) of PDMLA. Dynamic light scattering (DLS) studies gave particle z-average diameters between 11 and 74 nm (PDI = 0.04 to 0.20). Atomic force microscopy (AFM) showed evidence of spherical particles when dispersions were dried at ∼5 °C and film formation when dried at room temperature. Many of these polymers exhibited a reversible lower critical solution temperature (LCST) in water with a concomitant increase in z-average diameter for the PDMLA-b-PELA diblock copolymer nanoparticles.
    Àrees temàtiques: Renewable energy, sustainability and the environment Química Materiais Interdisciplinar Green & sustainable science & technology General chemistry General chemical engineering Farmacia Environmental chemistry Engineering, chemical Engenharias ii Engenharias i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemical engineering (miscellaneous) Chemical engineering (all) Biotecnología Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: marc.pala@urv.cat marc.pala@urv.cat gerard.lligadas@urv.cat
    Identificador de l'autor: 0000-0002-8519-1840
    Data d'alta del registre: 2024-08-03
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://pubs.acs.org/doi/10.1021/acssuschemeng.3c01112
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Acs Sustainable Chemistry & Engineering. 11 (27): 9979-9988
    Referència de l'ítem segons les normes APA: Woods, SE; Tinkler, JD; Bensabeh, N; Palà, M; Martin, SJ; Martin-Fabiani, I; Lligadas, G; Hatton, FL (2023). Temperature-Responsive Lactic Acid-Based Nanoparticles by RAFT-Mediated Polymerization-Induced Self-Assembly in Water. Acs Sustainable Chemistry & Engineering, 11(27), 9979-9988. DOI: 10.1021/acssuschemeng.3c01112
    DOI de l'article: 10.1021/acssuschemeng.3c01112
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2023
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Chemical Engineering (Miscellaneous),Chemistry (Miscellaneous),Chemistry, Multidisciplinary,Engineering, Chemical,Environmental Chemistry,Green & Sustainable Science & Technology,Renewable Energy, Sustainability and the Environment
    Thermoresponsive
    Temperature-responsive
    Raft
    Pisa
    Initio emulsion polymerization
    Green solvent
    Emulsion polymerization
    Biobased polymers
    Amphiphilic copolymers
    worms
    transition-temperatures
    thermoresponsive
    temperature-responsive
    radical polymerization
    pisa
    monomer
    green solvent
    fragmentation chain transfer
    ethyl lactate
    emulsion polymerization
    copolymer nano-objects
    biobasedpolymers
    amphiphilic copolymers
    acrylate
    Renewable energy, sustainability and the environment
    Química
    Materiais
    Interdisciplinar
    Green & sustainable science & technology
    General chemistry
    General chemical engineering
    Farmacia
    Environmental chemistry
    Engineering, chemical
    Engenharias ii
    Engenharias i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Chemical engineering (miscellaneous)
    Chemical engineering (all)
    Biotecnología
    Astronomia / física
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