Autor segons l'article: Biosca-Brull, J; Basaure, P; Guardia-Escote, L; Cabre, M; Blanco, J; Morales-Navas, M; Sánchez-Santed, F; Colomina, MT
Departament: Psicologia Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
Autor/s de la URV: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Guardia Escoté, Laia
Paraules clau: Ultrasonic vocalizations Development Cholinergic system Chlorpyrifos Autism Apoe genotype Anxiety-like behavior Anxiety weight-gain valproic acid ultrasonic vocalizations targeted replacement spectrum disorder rats gene cholinergic system chlorpyrifos autism apolipoprotein-e apoe genotype anxiety animal-model
Resum: Autism spectrum disorder (ASD) encompasses several neurodevelopmental conditions characterized by communication and social impairment, as well as repetitive patterns of behavior. However, it can co-occur with other mental conditions such as anxiety. The massive use of chlorpyrifos (CPF) has been linked to the increased prevalence of developmental disorders. Likewise, ASD has also been closely linked to a wide variety of genetic factors. The aims of the present investigation are to study how gestational CPF exposure and APOE polymorphism affects communication skills, early development and mid-term anxiety-like behaviors, as well as, changes in gene expression related to the cholinergic system. C57BL/6J and humanized apoE3 and apoE4 homozygous mice were exposed to 0 or 1 mg/kg/day of CPF through the diet, from gestational day (GD) 12-18. In addition, a group of C57BL/6J females were injected subcutaneously with 300 mg/kg/day of valproic acid (VPA) on GD 12 and 13. This group was used as a positive control for studying some core and associated autism-like behaviors. Communication skills by means of ultrasonic vocalizations and physical/motor development were assessed during the preweaning period, whereas locomotor activity, anxiety-like behaviors and the gene expression of cholinergic elements were evaluated during adolescence. Our results showed that C57BL/6J mice prenatally exposed to CPF or VPA showed a decrease in body weight and a delay in eye opening. Communication and anxiety behavior were affected differently depending on treatment, while gene expression was altered by sex and treatment. In addition, none of the parameters evaluated in apoE transgenic mice exposed to CPF were affected, but there were differences between genotypes. Therefore, we suggest that prenatal CPF exposure and VPA produce divergent effects on communication and anxiety.Copyright © 2023. Published by Elsevier Inc.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.blanco@urv.cat maria.cabre@urv.cat judit.biosca@urv.cat judit.biosca@urv.cat mariateresa.colomina@urv.cat
Identificador de l'autor: 0000-0001-8016-0984 0000-0003-4124-8603 0000-0002-5619-4874
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Environmental Research. 237 (Part 2): 116969-116969
Referència de l'ítem segons les normes APA: Biosca-Brull, J; Basaure, P; Guardia-Escote, L; Cabre, M; Blanco, J; Morales-Navas, M; Sánchez-Santed, F; Colomina, MT (2023). Environmental exposure to chlorpyrifos during gestation, APOE polymorphism and the risk on autistic-like behaviors. Environmental Research, 237(Part 2), 116969-116969. DOI: 10.1016/j.envres.2023.116969
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV