Autor segons l'article: Bernús, M; Mazzarella, D; Stanic, J; Zhai, ZR; Yeste-Vázquez, A; Boutureira, O; Gargano, AFG; Grossmann, TN; Noël, T
Departament: Química Analítica i Química Orgànica
Autor/s de la URV: Boutureira Martín, Omar
Paraules clau: Sufex click chemistry
Resum: Sulfur(VI) fluoride exchange click chemistry is a formidable tool to rapidly and effectively link chemical structures. Despite advances in the field in recent years, the installation of the sulfonyl fluoride handle still requires the use of purpose-designed, expensive and non-atom-economic reagents. The use of the SO2F2 for sulfonyl fluoride synthesis has been thwarted by the difficulties associated with the manipulation and dosage of this toxic gas, and by its apparent low reactivity with amino functionalities. Here we report a modular flow platform that can generate on demand, and efficiently dose, gaseous SO2F2. The use of flow technologies allows many lingering limitations of this transformation to be overcome, resulting in reduced reaction times, efficient reactivity and broad substrate scope. The effectiveness of the process was demonstrated by the successful synthesis of a diverse set of fluorosulfates and sulfamoyl fluorides, including those derived from biorelevant compounds, peptides and proteins. [Figure not available: see fulltext.].
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: omar.boutureira@urv.cat
Identificador de l'autor: 0000-0002-0768-8309
Data d'alta del registre: 2024-01-17
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.nature.com/articles/s44160-023-00441-0
Referència a l'article segons font original: Nature Synthesis.
Referència de l'ítem segons les normes APA: Bernús, M; Mazzarella, D; Stanic, J; Zhai, ZR; Yeste-Vázquez, A; Boutureira, O; Gargano, AFG; Grossmann, TN; Noël, T (2023). A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins. Nature Synthesis, (), -. DOI: 10.1038/s44160-023-00441-0
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1038/s44160-023-00441-0
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications