Autor segons l'article: Cortés-Espinar, AJ; Ibarz-Blanch, N; Soliz-Rueda, JR; Calvo, E; Bravo, FI; Mulero, M; Avila-Román, J
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Ávila Román, Francisco Javier / Bravo Vázquez, Francisca Isabel / Calvo Manso, Enrique
Paraules clau: Zeitgeber Phenolic compounds Oxidative stress Obesity Nrf2 pathway Metabolic syndrome Liver Lipid-metabolism Light Inflammation Gspe Gene-expression Circadian clock Chronotherapy Chronodisruption Cafeteria diet Body-weight
Resum: Disruptions of the light/dark cycle and unhealthy diets can promote misalignment of biological rhythms and metabolic alterations, ultimately leading to an oxidative stress condition. Grape seed proanthocyanidin extract (GSPE), which possesses antioxidant properties, has demonstrated its beneficial effects in metabolic-associated diseases and its potential role in modulating circadian disruptions. Therefore, this study aimed to assess the impact of GSPE administration on the liver oxidant system of healthy and diet-induced obese rats undergoing a sudden photoperiod shift. To this end, forty-eight photoperiod-sensitive Fischer 344/IcoCrl rats were fed either a standard (STD) or a cafeteria diet (CAF) for 6 weeks. A week before euthanizing, rats were abruptly transferred from a standard photoperiod of 12 h of light/day (L12) to either a short (6 h light/day, L6) or a long photoperiod (18 h light/day, L18) while receiving a daily oral dose of vehicle (VH) or GSPE (25 mg/kg). Alterations in body weight gain, serum and liver biochemical parameters, antioxidant gene and protein expression, and antioxidant metabolites were observed. Interestingly, GSPE partially ameliorated these effects by reducing the oxidative stress status in L6 through an increase in GPx1 expression and in hepatic antioxidant metabolites and in L18 by increasing the NRF2/KEAP1/ARE pathway, thereby showing potential in the treatment of circadian-related disorders by increasing the hepatic antioxidant response in a photoperiod-dependent manner.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: franciscaisabel.bravo@urv.cat enrique.calvo@urv.cat franciscojavier.avila@urv.cat
Identificador de l'autor: 0000-0002-6468-3088 0000-0001-9766-8178
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/24/23/17057
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 24 (23):
Referència de l'ítem segons les normes APA: Cortés-Espinar, AJ; Ibarz-Blanch, N; Soliz-Rueda, JR; Calvo, E; Bravo, FI; Mulero, M; Avila-Román, J (2023). Abrupt Photoperiod Changes Differentially Modulate Hepatic Antioxidant Response in Healthy and Obese Rats: Effects of Grape Seed Proanthocyanidin Extract (GSPE). International Journal Of Molecular Sciences, 24(23), -. DOI: 10.3390/ijms242317057
DOI de l'article: 10.3390/ijms242317057
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications