Autor segons l'article: Martin-Loeches, Ignacio; Maggi, Giampaolo; Diaz, Emili; Marin-Corral, Judith; Guedea, Alfonso; Restrepo, Marcos I; Reyes, Luis F; Rodriguez, Alejandro
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Rodríguez Oviedo, Alejandro Hugo
Paraules clau: Septic shock; Sepsis; Scap; S pneumoniae; Pneumonia; Mri; Mof; Icu; Endothelial damage
Resum: Background: Severe community-acquired pneumonia (sCAP) is the most frequent admission for acute respiratory failure in intensive care medicine. Observational studies have found a correlation between patients who were admitted with CAP and the development of cardiovascular events. The risk of acute myocardial damage in patients with CAP is particularly high within the first 30 days of hospitalization. Research design and methods: Multicenter prospective cohort analysis conducted in consecutive patients admitted to an ICU with microbiologically confirmed diagnoses of sCAP. The aim was to determine any structural cardiac damage detected by advanced imagining techniques (cardiac MRI) and cardiac biomarkers in patients with sCAP. The patients were stratified, according to their etiology, into pneumococcal or not-pneumococcal sCAP. The primary outcome was cardiac damage at day 5 and 7 of clinical presentation. Results: A total of 23 patients were consecutively and prospectively enrolled for two winter periods. No significant differences were observed between the median troponin when comparing the pneumococcal vs. non-pneumococcal. The incidence of myocardial damage was numerically higher in the pneumococcal subgroup (70% vs. 50%, p = 0.61) on day 5 and on day 7 (53% vs. 40%, p = 0.81) but did not achieve significance. Confirming a correlation between the biomarkers of cell damage and the biomarkers of myocardial damage, only a positive and significant correlation was observed between h-FABP and DNA on day 1 (r = 0.74; p < 0.01) and day 3 (r = 0.83; p < 0.010). Twenty cardiac MRIs were performed on the 23 patients (87%). No presence of fibrosis was observed in any of the studies carried out within the first 15 days of admission. Conclusions: No significant myocardial damage was found in patients with sCAP independent of the bacterial etiology in accordance with biomarker alterations (Troponin and/or h-FABP) or cardiac MRI. Using cardiac MRI, we could not find any presence of myocardial fibrosis within the first 15 days of admission.
Àrees temàtiques: Pharmacology, toxicology and pharmaceutics (miscellaneous); Pharmacology, toxicology and pharmaceutics (all); Pharmacology (medical); Pharmacology & pharmacy; Microbiology (medical); Microbiology; Infectious diseases; General pharmacology, toxicology and pharmaceutics; Engenharias ii; Biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: alejandrohugo.rodriguez@urv.cat
Data d'alta del registre: 2025-01-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2079-6382/12/12/1710
Referència a l'article segons font original: Antibiotics. 12 (12): 1710-
Referència de l'ítem segons les normes APA: Martin-Loeches, Ignacio; Maggi, Giampaolo; Diaz, Emili; Marin-Corral, Judith; Guedea, Alfonso; Restrepo, Marcos I; Reyes, Luis F; Rodriguez, Alejandro (2023). A Multicentric Observational Study to Determine Myocardial Injury in Severe Community-Acquired Pneumonia (sCAP). Antibiotics, 12(12), 1710-. DOI: 10.3390/antibiotics12121710
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3390/antibiotics12121710
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV