Autor segons l'article: Girona, J; Soler, O; Samino, S; Junza, A; Martínez-Micaelo, N; García-Altares, M; Ràfols, P; Esteban, Y; Yanes, O; Correig, X; Masana, L; Rodríguez-Calvo, R
Departament: Enginyeria Electrònica, Elèctrica i Automàtica Bioquímica i Biotecnologia Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/s de la URV: Correig Blanchar, Francesc Xavier / Garcia-Altares Pérez, Maria / Girona Tell, Josefa / Junza Martínez, Alexandra / Martínez Micaelo, Nieves Beatriz / Masana Marín, Luis / Ràfols Soler, Pere / Rodríguez Calvo, Ricardo / SAMINO GENÉ, SARA / SOLER BORONAT, ORIA / Yanes Torrado, Óscar
Paraules clau: Triglyceride content Steatosis Plasma-glucose Myocardial steatosis Metabolism Liver-disease Lipotoxicity Lipid peroxidation Diastolic dysfunction Diabetic cardiomyopathy Cardiac-function Cardiac lipotoxicity Adipose-tissue
Resum: Ectopic fat accumulation in non-adipose tissues is closely related to diabetes-related myocardial dysfunction. Nevertheless, the complete picture of the lipid metabolites involved in the metabolic-related myocardial alterations is not fully characterized. The aim of this study was to characterize the specific lipid profile in hearts in an animal model of obesity/insulin resistance induced by a high-fat diet (HFD). The cardiac lipidome profiles were assessed via liquid chromatography-mass spectrometry (LC-MS)/MS-MS and laser desorption/ionization-mass spectrometry (LDI-MS) tissue imaging in hearts from C57BL/6J mice fed with an HFD or standard-diet (STD) for 12 weeks. Targeted lipidome analysis identified a total of 63 lipids (i.e., 48 triacylglycerols (TG), 5 diacylglycerols (DG), 1 sphingomyelin (SM), 3 phosphatidylcholines (PC), 1 DihydroPC, and 5 carnitines) modified in hearts from HFD-fed mice compared to animals fed with STD. Whereas most of the TG were up-regulated in hearts from animals fed with an HFD, most of the carnitines were down-regulated, thereby suggesting a reduction in the mitochondrial beta-oxidation. Roughly 30% of the identified metabolites were oxidated, pointing to an increase in lipid peroxidation. Cardiac lipidome was associated with a specific biochemical profile and a specific liver TG pattern. Overall, our study reveals a specific cardiac lipid fingerprint associated with metabolic alterations induced by HFD.
Àrees temàtiques: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: josefa.girona@urv.cat ricardo.rodriguez@urv.cat oscar.yanes@urv.cat neus.martinez@urv.cat oria.soler@urv.cat pere.rafols@urv.cat alexandra.junza@urv.cat maria.garcia-altares@urv.cat luis.masana@urv.cat xavier.correig@urv.cat josefa.girona@urv.cat
Identificador de l'autor: 0000-0002-6267-8779 0000-0003-3695-7157 0000-0002-9240-4058 0000-0001-7205-0419 0000-0002-0789-4954 0000-0002-6902-3054 0000-0002-6267-8779
Data d'alta del registre: 2024-05-23
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/25/5/2702
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Molecular Sciences. 25 (5): 2702-
Referència de l'ítem segons les normes APA: Girona, J; Soler, O; Samino, S; Junza, A; Martínez-Micaelo, N; García-Altares, M; Ràfols, P; Esteban, Y; Yanes, O; Correig, X; Masana, L; Rodríguez-Ca (2024). Lipidomics Reveals Myocardial Lipid Composition in a Murine Model of Insulin Resistance Induced by a High-Fat Diet. International Journal Of Molecular Sciences, 25(5), 2702-. DOI: 10.3390/ijms25052702
DOI de l'article: 10.3390/ijms25052702
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2024
Tipus de publicació: Journal Publications
Repositori URV