Glycated hemoglobin, type 2 diabetes, and poor diabetes control are positively associated with impulsivity changes in aged individuals with overweight or obesity and metabolic syndrome

Autor segons l'article: Gomez-Martinez, Carlos; Babio, Nancy; Camacho-Barcia, Lucia; Julvez, Jordi; Nishi, Stephanie K; Vazquez, Zenaida; Forcano, Laura; Alvarez-Sala, Andrea; Cuenca-Royo, Aida; de la Torre, Rafael; Fanlo-Maresma, Marta; Tello, Susanna; Corella, Dolores; Vasquez, Alejandro Arias; Dalsgaard, Soren; Franke, Barbara; Fernandez-Aranda, Fernando; Salas-Salvado, Jordi

Departament: Bioquímica i Biotecnologia

Autor/s de la URV: Babio Sánchez, Nancy Elvira / Gómez Martínez, Carlos / Nishi, Stephanie Kimiko / Salas Salvadó, Jorge

Paraules clau: Validity; Type 2 diabetes mellitus; Type 2 diabetes mellitu; Type 2 diabetes control; Ris; Prospective studies; Personality; Oxidative stress; Overweight; Obesity; Midlife; Middle aged; Metabolic syndrome; Male; Insulin-resistance; Insulin resistance (homa‐ir); Insulin resistance (homa-ir); Insulin resistance; Impulsivity; Impulsive behavior; Humans; Hemoglobin a1c protein, human; Glycemic control; Glycated hemoglobin (hba1c); Glycated hemoglobin; Female; Diabetes mellitus, type 2; Cognition; Blood-glucose; Aged; Adherence

Resum: Impulsivity has been proposed to have an impact on glycemic dysregulation. However, it remains uncertain whether an unfavorable glycemic status could also contribute to an increase in impulsivity levels. This study aims to analyze associations of baseline and time-varying glycemic status with 3-year time-varying impulsivity in older adults at high risk of cardiovascular disease. A 3-year prospective cohort design was conducted within the PREDIMED-Plus-Cognition substudy. The total population includes 487 participants (mean age = 65.2 years; female = 50.5%) with overweight or obesity and metabolic syndrome. Insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), presence of type 2 diabetes mellitus, and type 2 diabetes control were evaluated. Impulsivity was measured using the Impulsive Behavior Scale questionnaire and various cognitive measurements. Impulsivity z-scores were generated to obtain Global, Trait, and Behavioral Impulsivity domains. Linear mixed models were used to study the longitudinal associations across baseline, 1-year, and 3-year follow-up visits. HOMA-IR was not significantly related to impulsivity. Participants with higher HbA1c levels, type 2 diabetes, and poor control of diabetes showed positive associations with the Global Impulsivity domain over time, and those with higher HbA1c levels were further related to increases in the Trait and Behavioral Impulsivity domains over the follow-up visits. These results suggest a potential positive feedback loop between impulsivity and glycemic-related dysregulation. Previous studies have examined associations between glycemic-related factors and impulsivity, but mostly in cross-sectional studies with a lack of using both trait and behavioral impulsivity assessments together. Using the PREDIMED-Plus-Cognition cohort, several glycemic-related and impulsivity assessments were obtained over 3 years. Z-scores of impulsivity domains were obtained to provide a comprehensive impulsivity evaluation. Based on previous evidence, the current results suggest a positive feedback loop between impulsivity and glycemic dysregulations. image

Àrees temàtiques: Saúde coletiva; Química; Psicología; Nutrição; Neuroscience (miscellaneous); Neuroscience (all); Multidisciplinary sciences; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; History and philosophy of science; Historia y filosofía de la ciencia; Geociências; General o multidisciplinar; General neuroscience; General medicine; General biochemistry,genetics and molecular biology; Farmacia; Enfermagem; Ciencias sociales; Ciencias humanas; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Biotecnología; Biodiversidade; Biochemistry, genetics and molecular biology (miscellaneous); Biochemistry, genetics and molecular biology (all)

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: stephanie.nishi@urv.cat; carlos.gomezm@estudiants.urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat

Data d'alta del registre: 2025-03-15

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Enllaç font original: https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/nyas.15205

Referència a l'article segons font original: Annals Of The New York Academy Of Sciences. 1540 (1): 211-224

Referència de l'ítem segons les normes APA: Gomez-Martinez, Carlos; Babio, Nancy; Camacho-Barcia, Lucia; Julvez, Jordi; Nishi, Stephanie K; Vazquez, Zenaida; Forcano, Laura; Alvarez-Sala, Andrea (2024). Glycated hemoglobin, type 2 diabetes, and poor diabetes control are positively associated with impulsivity changes in aged individuals with overweight or obesity and metabolic syndrome. Annals Of The New York Academy Of Sciences, 1540(1), 211-224. DOI: 10.1111/nyas.15205

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

DOI de l'article: 10.1111/nyas.15205

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2024

Tipus de publicació: Journal Publications