Articles producció científicaBioquímica i Biotecnologia

Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study

  • Dades identificatives

    Identificador:  imarina:9383127
    Handle: https://hdl.handle.net/20.500.11797/imarina9383127
    Autors:  Wimberley, Theresa; Brikell, Isabell; Astrup, Aske; Larsen, Janne T; Petersen, Liselotte V; Albinana, Clara; Vilhjalmsson, Bjarni J; Bulik, Cynthia M; Chang, Zheng; Fanelli, Giuseppe; Bralten, Janita; Mota, Nina R; Salas-Salvado, Jordi; Fernandez-Aranda, Fernando; Bullo, Monica; Franke, Barbara; Borglum, Anders; Mortensen, Preben B; Horsdal, Henriette T; Dalsgaard, Soren
    Resum:
    Background Psychiatric disorders and type 2 diabetes mellitus (T2DM) are heritable, polygenic, and often comorbid conditions, yet knowledge about their potential shared familial risk is lacking. We used family designs and T2DM polygenic risk score (T2DM-PRS) to investigate the genetic associations between psychiatric disorders and T2DM.Methods We linked 659 906 individuals born in Denmark 1990-2000 to their parents, grandparents, and aunts/uncles using population-based registers. We compared rates of T2DM in relatives of children with and without a diagnosis of any or one of 11 specific psychiatric disorders, including neuropsychiatric and neurodevelopmental disorders, using Cox regression. In a genotyped sample (iPSYCH2015) of individuals born 1981-2008 (n = 134 403), we used logistic regression to estimate associations between a T2DM-PRS and these psychiatric disorders.Results Among 5 235 300 relative pairs, relatives of individuals with a psychiatric disorder had an increased risk for T2DM with stronger associations for closer relatives (parents:hazard ratio = 1.38, 95% confidence interval 1.35-1.42; grandparents: 1.14, 1.13-1.15; and aunts/uncles: 1.19, 1.16-1.22). In the genetic sample, one standard deviation increase in T2DM-PRS was associated with an increased risk for any psychiatric disorder (odds ratio = 1.11, 1.08-1.14). Both familial T2DM and T2DM-PRS were significantly associated with seven of 11 psychiatric disorders, most strongly with attention-deficit/hyperactivity disorder and conduct disorder, and inversely with anorexia nervosa.Conclusions Our findings of familial co-aggregation and higher T2DM polygenic liability associated with psychiatric disorders point toward shared familial risk. This suggests that part of the comorbidity is explained by shared

  • Altres:

    Autor segons l'article: Wimberley, Theresa; Brikell, Isabell; Astrup, Aske; Larsen, Janne T; Petersen, Liselotte V; Albinana, Clara; Vilhjalmsson, Bjarni J; Bulik, Cynthia M; Chang, Zheng; Fanelli, Giuseppe; Bralten, Janita; Mota, Nina R; Salas-Salvado, Jordi; Fernandez-Aranda, Fernando; Bullo, Monica; Franke, Barbara; Borglum, Anders; Mortensen, Preben B; Horsdal, Henriette T; Dalsgaard, Soren
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Paraules clau: Polygenic risk; Polygenic ris; Non-insulin-dependent diabetes mellitus; Insulin resistance; Genetic overlap; Familial co-aggregation
    Resum: Background Psychiatric disorders and type 2 diabetes mellitus (T2DM) are heritable, polygenic, and often comorbid conditions, yet knowledge about their potential shared familial risk is lacking. We used family designs and T2DM polygenic risk score (T2DM-PRS) to investigate the genetic associations between psychiatric disorders and T2DM.Methods We linked 659 906 individuals born in Denmark 1990-2000 to their parents, grandparents, and aunts/uncles using population-based registers. We compared rates of T2DM in relatives of children with and without a diagnosis of any or one of 11 specific psychiatric disorders, including neuropsychiatric and neurodevelopmental disorders, using Cox regression. In a genotyped sample (iPSYCH2015) of individuals born 1981-2008 (n = 134 403), we used logistic regression to estimate associations between a T2DM-PRS and these psychiatric disorders.Results Among 5 235 300 relative pairs, relatives of individuals with a psychiatric disorder had an increased risk for T2DM with stronger associations for closer relatives (parents:hazard ratio = 1.38, 95% confidence interval 1.35-1.42; grandparents: 1.14, 1.13-1.15; and aunts/uncles: 1.19, 1.16-1.22). In the genetic sample, one standard deviation increase in T2DM-PRS was associated with an increased risk for any psychiatric disorder (odds ratio = 1.11, 1.08-1.14). Both familial T2DM and T2DM-PRS were significantly associated with seven of 11 psychiatric disorders, most strongly with attention-deficit/hyperactivity disorder and conduct disorder, and inversely with anorexia nervosa.Conclusions Our findings of familial co-aggregation and higher T2DM polygenic liability associated with psychiatric disorders point toward shared familial risk. This suggests that part of the comorbidity is explained by shared familial risks. The underlying mechanisms still remain largely unknown and the contributions of genetics and environment need further investigation.
    Àrees temàtiques: Saúde coletiva; Psychology, clinical; Psychology; Psychiatry and mental health; Psychiatry; Psicología; Medicina ii; Medicina i; Interdisciplinar; General medicine; Educação; Ciencias sociales; Ciências biológicas ii; Ciências biológicas i; Applied psychology; Antropologia / arqueologia
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: monica.bullo@urv.cat; jordi.salas@urv.cat
    Data d'alta del registre: 2025-02-18
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.cambridge.org/core/journals/psychological-medicine/article/shared-familial-risk-for-type-2-diabetes-mellitus-and-psychiatric-disorders-a-nationwide-multigenerational-genetics-study/32A3771296E951107C541E32CD61C5DA
    Referència a l'article segons font original: Psychological Medicine. 54 (11): 2976-2985
    Referència de l'ítem segons les normes APA: Wimberley, Theresa; Brikell, Isabell; Astrup, Aske; Larsen, Janne T; Petersen, Liselotte V; Albinana, Clara; Vilhjalmsson, Bjarni J; Bulik, Cynthia M; (2024). Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study. Psychological Medicine, 54(11), 2976-2985. DOI: 10.1017/S0033291724001053
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1017/S0033291724001053
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications

  • Paraules clau:

    Applied Psychology,Psychiatry,Psychiatry and Mental Health,Psychology,Psychology, Clinical
    Polygenic risk
    Polygenic ris
    Non-insulin-dependent diabetes mellitus
    Insulin resistance
    Genetic overlap
    Familial co-aggregation
    Saúde coletiva
    Psychology, clinical
    Psychology
    Psychiatry and mental health
    Psychiatry
    Psicología
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Educação
    Ciencias sociales
    Ciências biológicas ii
    Ciências biológicas i
    Applied psychology
    Antropologia / arqueologia

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