Autor segons l'article: Pàmies A; Llop D; Ibarretxe D; Rosales R; Girona J; Masana L; Vallvé JC; Paredes S
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Girona Tell, Josefa / Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / Pàmies Corts, Anna / PAREDES EGEA, SERGI / ROSALES RIBAS, ROSER / Vallvé Torrente, Joan Carles
Paraules clau: Adult; Aged; Ahsg protein, human; Alpha-2-hs-glycoprotein; Anti-citrullinated protein antibodies; Arthritis, rheumatoid; Atherosclerosis; Biomarkers; Blood proteins; Cardiovascular disease; Cardiovascular diseases; Carotid intima-media thickness; Chromogranin a; Chromogranin a (344-364); Dkk1 protein, human; Female; Galectins; Humans; Intercellular signaling peptides and proteins; Lgals3 protein, human; Male; Middle aged; Peptide fragments; Rheumatoid arthritis; Rheumatoid factor
Resum: Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with increased cardiovascular disease (CVD) risk and mortality. This work aimed to evaluate the serum levels of the novel CV biomarkers fetuin-A (fet-A), Dickkopf-1 (DKK-1), galectin-3 (Gal-3), interleukin-32 (IL-32), and catestatin (CST) in RA patients and their associations with RA parameters and CVD markers. A cohort of 199 RA patients was assessed for traditional CVD risk factors, RA disease activity, and biomarker levels. Carotid ultrasound was used to measure carotid intima-media thickness (cIMT) and carotid plaque presence (cPP). Multivariate analyses examined correlations between biomarkers and RA parameters, serological markers, and CVD markers. Adjusted models showed that elevated CST expression levels were associated with rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) positivity (OR = 2.45, <i>p</i> = 0.0001 and OR = 1.48, <i>p</i> = 0.04, respectively) in the overall cohort and for RF in men and women, respectively. In addition, fet-A concentration was inversely associated with the erythrocyte sedimentation rate (ESR) in the overall cohort (β = -0.15, <i>p</i> = 0.038) and in women (β = -0.25, <i>p</i> = 0.004). Fet-A levels were also negatively correlated with disease activity (DAS28-ESR) scores (β = -0.29, <i>p</i> = 0.01) and fibrinogen concentration (β = -0.22, <i>p</i> = 0.01) in women. No adjusted associations were observed for Gal-3, DKK-1 or IL32 concentration. The study revealed no significant associations between the biomarkers and cIMT or cPP. The measurement of CST and fet-A levels could enhance RA patient management and prognosis. However, the utility of biomarkers for evaluating CV risk via traditional surrogate markers is limited, highlighting the need for continued investigations into their roles in RA.
Àrees temàtiques: Astronomia / física; Biochemistry & molecular biology; Biodiversidade; Biotecnología; Catalysis; Chemistry, multidisciplinary; Ciência da computação; Ciência de alimentos; Ciências agrárias i; Ciências ambientais; Ciências biológicas i; Ciências biológicas ii; Ciências biológicas iii; Computer science applications; Educação física; Engenharias i; Engenharias ii; Engenharias iv; Farmacia; Geociências; Inorganic chemistry; Interdisciplinar; Materiais; Medicina i; Medicina ii; Medicina iii; Medicina veterinaria; Medicine (miscellaneous); Molecular biology; Nutrição; Odontología; Organic chemistry; Physical and theoretical chemistry; Psicología; Química; Saúde coletiva; Spectroscopy; Zootecnia / recursos pesqueiros
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: luis.masana@urv.cat; jc.vallve@urv.cat; josefa.girona@urv.cat; anna.pamies@estudiants.urv.cat; didac.llop@urv.cat; jc.vallve@urv.cat; josefa.girona@urv.cat; daiana.ibarretxe@urv.cat; didac.llop@urv.cat
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/25/18/9910
Referència a l'article segons font original: International Journal Of Molecular Sciences. 25 (18): 9910-9910
Referència de l'ítem segons les normes APA: Pàmies A; Llop D; Ibarretxe D; Rosales R; Girona J; Masana L; Vallvé JC; Paredes S (2024). Enhanced Association of Novel Cardiovascular Biomarkers Fetuin-A and Catestatin with Serological and Inflammatory Markers in Rheumatoid Arthritis Patients.. International Journal Of Molecular Sciences, 25(18), 9910-9910. DOI: 10.3390/ijms25189910
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3390/ijms25189910
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2024
Tipus de publicació: Journal Publications
Repositori URV