Articles producció científica> Enginyeria Química

Impact of mechanical power on ICU mortality in ventilated critically ill patients: a retrospective study with continuous real-life data

  • Dades identificatives

    Identificador: imarina:9387490
    Autors:
    Manrique, SaraRuiz-Botella, ManuelMurillo, NataliaCanelles, SandraVictoria, Ivan DavidSamper, Manuel AndresPlans, OriolClaverias, LauraMagret, MonicaGordo, FedericoRoca, OriolBodi, Maria
    Resum:
    Background Over the past decade, numerous studies on potential factors contributing to ventilation-induced lung injury have been carried out. Mechanical power has been pointed out as the parameter that encloses all ventilation-induced lung injury-contributing factors. However, studies conducted to date provide data regarding mechanical power during the early hours of mechanical ventilation that may not accurately reflect the impact of power throughout the period of mechanical ventilatory support on intensive care unit mortality. Methods Retrospective observational study conducted at a single center in Spain. Patients admitted to the intensive care unit, > o = 18 years of age, and ventilated for over 24 h were included. We extracted the mechanical power values throughout the entire mechanical ventilation in controlled modes period from the clinical information system every 2 min. First, we calculate the cutoff-point for mechanical power beyond which there was a greater change in the probability of death. After, the sum of time values above the safe cut-off point was calculated to obtain the value in hours. We analyzed if the number of hours the patient was under ventilation with a mechanical power above the safe threshold was associated with intensive care unit mortality, invasive mechanical ventilation days, and intensive care unit length of stay. We repeated the analysis in different subgroups based on the degree of hypoxemia and in patients with SARS CoV-2 pneumonia. Results The cut-off point of mechanical power at with there is a higher increase in intensive care unit mortality was 18 J/min. The greater the number of hours patients were under mechanical power > 18 J/min the higher the intensive care unit mortality in all the study population, in patients with SARS Co
  • Altres:

    Autor segons l'article: Manrique, Sara; Ruiz-Botella, Manuel; Murillo, Natalia; Canelles, Sandra; Victoria, Ivan David; Samper, Manuel Andres; Plans, Oriol; Claverias, Laura; Magret, Monica; Gordo, Federico; Roca, Oriol; Bodi, Maria
    Departament: Enginyeria Química
    Autor/s de la URV: Bodi Saera, Maria Amparo / Manrique Moreno, Sara / Ruiz Botella, Manuel
    Paraules clau: Ventilator-induced lung injury Ventilation-induced lung injury Strai Spain Sars-cov2 Sars-cov-2 Retrospective studies Respiratory-distress-syndrome Respiration, artificial Pulmonary complications Protective mechanical ventilation Middle aged Mechanical ventilation Mechanical power Male Lower tidal volumes Length of stay Intensive care units Inspiratory flow Induced lung injury Humans Hospital mortality Female Failure Describe Critical illness Covid-19 Clinical information system Clinical information syste Aged
    Resum: Background Over the past decade, numerous studies on potential factors contributing to ventilation-induced lung injury have been carried out. Mechanical power has been pointed out as the parameter that encloses all ventilation-induced lung injury-contributing factors. However, studies conducted to date provide data regarding mechanical power during the early hours of mechanical ventilation that may not accurately reflect the impact of power throughout the period of mechanical ventilatory support on intensive care unit mortality. Methods Retrospective observational study conducted at a single center in Spain. Patients admitted to the intensive care unit, > o = 18 years of age, and ventilated for over 24 h were included. We extracted the mechanical power values throughout the entire mechanical ventilation in controlled modes period from the clinical information system every 2 min. First, we calculate the cutoff-point for mechanical power beyond which there was a greater change in the probability of death. After, the sum of time values above the safe cut-off point was calculated to obtain the value in hours. We analyzed if the number of hours the patient was under ventilation with a mechanical power above the safe threshold was associated with intensive care unit mortality, invasive mechanical ventilation days, and intensive care unit length of stay. We repeated the analysis in different subgroups based on the degree of hypoxemia and in patients with SARS CoV-2 pneumonia. Results The cut-off point of mechanical power at with there is a higher increase in intensive care unit mortality was 18 J/min. The greater the number of hours patients were under mechanical power > 18 J/min the higher the intensive care unit mortality in all the study population, in patients with SARS CoV-2 pneumonia and in mild to moderate hypoxemic respiratory failure. The risk of death in the intensive care unit increases 0.1% for each hour with mechanical power exceeding 18 J/min. The number of hours with mechanical power > 18 J/min also affected the days of invasive mechanical ventilation and intensive care unit length of stay. Conclusions The number of hours with mechanical power > 18 J/min is associated with mortality in the intensive care unit in critically ill patients. Continuous monitoring of mechanical power in controlled modes using an automated clinical information system could alert the clinician to this risk.
    Àrees temàtiques: Saúde coletiva Química Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas iii
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: manuel.ruiz@urv.cat sara.manrique@estudiants.urv.cat mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
    Identificador de l'autor: 0000-0001-7652-8379 0000-0001-7652-8379
    Data d'alta del registre: 2025-01-28
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: European Journal Of Medical Research. 29 (1): 491-
    Referència de l'ítem segons les normes APA: Manrique, Sara; Ruiz-Botella, Manuel; Murillo, Natalia; Canelles, Sandra; Victoria, Ivan David; Samper, Manuel Andres; Plans, Oriol; Claverias, Laura; (2024). Impact of mechanical power on ICU mortality in ventilated critically ill patients: a retrospective study with continuous real-life data. European Journal Of Medical Research, 29(1), 491-. DOI: 10.1186/s40001-024-02082-1
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Medicine, Research & Experimental
    Ventilator-induced lung injury
    Ventilation-induced lung injury
    Strai
    Spain
    Sars-cov2
    Sars-cov-2
    Retrospective studies
    Respiratory-distress-syndrome
    Respiration, artificial
    Pulmonary complications
    Protective mechanical ventilation
    Middle aged
    Mechanical ventilation
    Mechanical power
    Male
    Lower tidal volumes
    Length of stay
    Intensive care units
    Inspiratory flow
    Induced lung injury
    Humans
    Hospital mortality
    Female
    Failure
    Describe
    Critical illness
    Covid-19
    Clinical information system
    Clinical information syste
    Aged
    Saúde coletiva
    Química
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Enfermagem
    Ciências biológicas iii
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