Gut microbiota dynamics and association with chronic kidney disease: A longitudinal study within the PREDIMED-Plus trial

Identificador:  imarina:9388775

Handle: https://hdl.handle.net/20.500.11797/imarina9388775

Autors:  Atzeni, Alessandro; Diaz-Lopez, Andres; Cacho, Adrian Hernandez; Babio, Nancy; Garcia-Gavilan, Jesus F; Cornejo-Pareja, Isabel; Belzer, Clara; Fito, Montserrat; Tinahones, Francisco J; Salas-Salvado, Jordi

Resum:
Aims: Chronic kidney disease (CKD) represents a global health concern, disproportionately affecting the elderly with heightened cardiovascular risk. The emerging focus on the gut microbiota's role in CKD pathophysiology represents a pivotal area in nephrology; however, the evidence on this topic is limited. This observational prospective study, in the framework of the PREDIMED-Plus trial, investigates associations between gut microbiota composition and the 1-year trajectory of CKD in 343 participants aged 55-75 years with high cardiovascular risk. Materials and methods: Kidney function was assessed at baseline and at 1-year of follow-up through the estimated glomerular filtration rate based on cystatin C (eGFR-CysC) and CKD defined by eGFR-CysC