Autor segons l'article: Salvador-Martin, Sara; Zapata-Cobo, Paula; Velasco, Marta; Palomino, Laura M; Clemente, Susana; Segarra, Oscar; Sanchez, Cesar; Tolin, Mar; Moreno-alvarez, Ana; Fernandez-Lorenzo, Ana; Perez-Moneo, Begona; Loverdos, Ines; Navas Lopez, Victor Manuel; Millan, Antonio; Magallares, Lorena; Torres-Peral, Ricardo; Garcia-Romero, Ruth; Pujol-Muncunill, Gemma; Merino-Bohorquez, Vicente; Rodriguez, Alejandro; Salcedo, Enrique; Lopez-Cauce, Beatriz; Marin-Jimenez, Ignacio; Menchen, Luis; Laserna-Mendieta, Emilio; Lucendo, Alfredo J; Sanjurjo-Saez, Maria; Lopez-Fernandez, Luis A
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Rodríguez Oviedo, Alejandro Hugo
Paraules clau: Single nucleotide polymorphism; Predictor; Pharmacogenetics; Infliximab; Immunogenicity; Haplotypes; Antibodies; Adalimuma
Resum: The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age diagnosed with IBD and treated with anti-TNF drugs from a network of Spanish hospitals. Genotypes and failure of anti-TNF drugs were analyzed using Kaplan-Meier curves and Cox logistic regression. The homozygous G allele of rs2395185 and the C allele of rs2097432 were associated with impaired long-term response to anti-TNF drugs in children with IBD after 3 and 9 years of follow-up. Being a carrier of both polymorphisms increased the risk of anti-TNF failure. The SNP rs2395185 but not rs2097432 was associated with response to infliximab in adults with CD treated with infliximab but not in children after 3 or 9 years of follow-up. Conclusions: SNPs rs2395185 and rs2097432 were associated with a long-term response to anti-TNFs in IBD in Spanish children. Differences between adults and children were observed in patients diagnosed with CD and treated with infliximab.
Àrees temàtiques: Zootecnia / recursos pesqueiros; Spectroscopy; Saúde coletiva; Química; Psicología; Physical and theoretical chemistry; Organic chemistry; Odontología; Nutrição; Molecular biology; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Inorganic chemistry; Geociências; Farmacia; Engenharias iv; Engenharias ii; Engenharias i; Educação física; Computer science applications; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Chemistry, multidisciplinary; Catalysis; Biotecnología; Biodiversidade; Biochemistry & molecular biology; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: alejandrohugo.rodriguez@urv.cat
Data d'alta del registre: 2025-01-27
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/1422-0067/24/2/1797
Referència a l'article segons font original: International Journal Of Molecular Sciences. 24 (2): 1797-
Referència de l'ítem segons les normes APA: Salvador-Martin, Sara; Zapata-Cobo, Paula; Velasco, Marta; Palomino, Laura M; Clemente, Susana; Segarra, Oscar; Sanchez, Cesar; Tolin, Mar; Moreno-alv (2023). Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort. International Journal Of Molecular Sciences, 24(2), 1797-. DOI: 10.3390/ijms24021797
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3390/ijms24021797
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV