Autor segons l'article: Herrero, Merce; Broner, Sonia; Cruells, Adria; Esteve, Silvia; Ferre, Lourdes; Mendioroz, Jacobo; Jane, Mireia
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Gomez Bertomeu, Frederic-Francesc
Paraules clau: Susceptibility; Spain; Retrospective studies; Neisseria gonorrhoeae; Multi-drug resistant; Microbial sensitivity tests; Humans; Gonorrhea; Drug resistance, bacterial; Ciprofloxacin; Chlamydi; Ceftriaxone; Azithromycin; Antimicrobial resistance; Antimicrobial resistanc; Anti-bacterial agents
Resum: Antimicrobial resistance data for Neisseria gonorrhoeae is globally sparse and resistant strains are emerging in Catalonia. We aim to describe epidemiological and antimicrobial resistance in all patients infected with N. gonorrhoeae during the period from 2016 to 2019, using available antimicrobial susceptibility data. We retrospectively analysed confirmed N. gonorrhoeae cases notified to Catalonia's microbiological reporting system. Antibiotic susceptibility testing (azithromycin, cefixime, ceftriaxone, ciprofloxacin, penicillin, spectinomycin, and tetracycline) was assessed using clinical breakpoints published by the European Committee on Antimicrobial Susceptibility Testing. Incidence rates were calculated and proportions were compared using the chi(2) test or Fisher's exact test, and analysed using the Statistical Package for Social Sciences (SPSS 18.0). A total of 14,251 confirmed cases of N. gonorrhoeae were notified. Incidence increased from 30.7 cases/100,000 person-years (p < 0.001) in 2016 to 64.7 in 2019. Culture was available in 6,292 isolates (44.2%), of which 5,377 (85.5%) were resistant to at least one of the antibiotics tested. Azithromycin resistance rose from 6.1% in 2016 to 16% in 2019 (p < 0.001). Only 1.0% (45 cases) were resistant to ceftriaxone. Multidrug-resistant N. gonorrhoeae increased from 0.25% in 2016 to 0.42% in 2019 (p = 0.521). One case presented extensively drug-resistant N. gonorrhoeae. In Catalonia, 10% of the N. gonorrhoeae isolates were resistant to azithromycin in the 2016-2019 period. According to World Health Organization guidelines, resistance above 5% indicates an alert to review treatment guidelines. Antimicrobial susceptibility testing in clinical practice followed by surveillance and interventions are essential to monitor trends and prevent the spread of antimicrobial resistance.
Àrees temàtiques: Saúde coletiva; Odontología; Microbiology (medical); Microbiology; Medicine (miscellaneous); Medicina veterinaria; Medicina ii; Medicina i; Interdisciplinar; Infectious diseases; Farmacia; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Biotecnología; Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: frederic-francesc.gomez@urv.cat
Data d'alta del registre: 2025-02-19
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://link.springer.com/article/10.1007/s10096-023-04601-0
Referència a l'article segons font original: European Journal Of Clinical Microbiology & Infectious Diseases. 42 (7): 883-893
Referència de l'ítem segons les normes APA: Herrero, Merce; Broner, Sonia; Cruells, Adria; Esteve, Silvia; Ferre, Lourdes; Mendioroz, Jacobo; Jane, Mireia (2023). Epidemiology and antimicrobial resistance profile of Neisseria gonorrhoeae in Catalonia, Spain, 2016-2019. European Journal Of Clinical Microbiology & Infectious Diseases, 42(7), 883-893. DOI: 10.1007/s10096-023-04601-0
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1007/s10096-023-04601-0
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV