Autor segons l'article: López-Laguna N; Toledo E; Hershey MS; Babio N; Sorlí JV; Ros E; Muñoz MÁ; Estruch R; Lapetra J; Muñoz-Bravo C; Fiol M; Bautista-Castaño I; Pinto X; Ortega-Azorín C; Hernando-Redondo J; Salas-Salvadó J; Tojal-Sierra L; Martínez-González MA; Ruiz-Canela M
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Paraules clau: Aged; Blood pressure; Body mass index; Cardiovascular health; Diet, mediterranean; Exercise; Female; Heart disease risk factors; Humans; Incidence; Life’s simple 7; Male; Mediterranean diet; Middle aged; Peripheral arterial disease; Peripheral artery disease; Predimed study; Prevention; Proportional hazards models; Prospective studies; Risk factors
Resum: Peripheral artery disease (PAD) is a major vascular condition often overlooked in prevention strategies. We aimed to evaluate the association between cardiovascular health, measured by Life's Simple 7 (LS7), and the risk of PAD in a high-risk Mediterranean population. This prospective analysis included 7122 participants from the PREDIMED study (Prevención con Dieta Mediterránea) at high cardiovascular risk but free of cardiovascular disease at baseline. LS7 scores (0-14 points) were calculated using seven metrics: smoking status, body mass index, physical activity, blood pressure, total cholesterol, glucose metabolism, and adherence to the Mediterranean diet. Participants were categorized into inadequate (0-5), average (6-8), and optimal (9-14) cardiovascular health. Multivariable Cox regression models and Nelson-Aalen curves assessed the association between LS7 and PAD incidence over a median 4.8-year follow-up. A meta-analysis combining these results with three prior studies was also performed. A total of 87 incident PAD cases were identified. Compared to participants with inadequate cardiovascular health, those with average and optimal LS7 scores exhibited significantly lower PAD risk (adjusted hazard ratio [HR] 0.37; 95% confidence interval [CI]: 0.22-0.61, and HR 0.25; 95% CI: 0.10-0.65, respectively). Each one-point increase in the LS7 score (range 0 to 14) was associated with an 22% lower PAD risk (HR 0.78; 95% CI: 0.68-0.90). The meta-analysis yielded a pooled HR of 0.81 (95% CI: 0.76-0.87), confirming consistent inverse associations across populations. Greater adherence to LS7 metrics is associated with a significantly reduced risk of PAD in high-risk Mediterranean individuals. Promoting LS7 adherence may represent an effective strategy for preventing both cardiovascular disease and PAD.
Àrees temàtiques: Biotecnología; Ciência de alimentos; Ciências agrárias i; Ciências biológicas i; Ciências biológicas ii; Ciências biológicas iii; Economia; Educação física; Enfermagem; Engenharias ii; Engenharias iv; Farmacia; Food science; Interdisciplinar; Medicina i; Medicina ii; Medicina iii; Medicina veterinaria; Nutrição; Nutrition & dietetics; Nutrition and dietetics; Planejamento urbano e regional / demografia; Psicología; Química; Saúde coletiva; Zootecnia / recursos pesqueiros
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Data d'alta del registre: 2025-07-19
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.mdpi.com/2072-6643/17/13/2058
Referència a l'article segons font original: Nutrients. 17 (13):
Referència de l'ítem segons les normes APA: López-Laguna N; Toledo E; Hershey MS; Babio N; Sorlí JV; Ros E; Muñoz MÁ; Estruch R; Lapetra J; Muñoz-Bravo C; Fiol M; Bautista-Castaño I; Pinto X; Or (2025). Life's Simple 7 and Risk of Peripheral Artery Disease: Results from the PREDIMED Study and an Updated Meta-Analysis.. Nutrients, 17(13), -. DOI: 10.3390/nu17132058
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.3390/nu17132058
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2025
Tipus de publicació: Journal Publications
Repositori URV