Articles producció científica> Medicina i Cirurgia

Effects of low molecular weight procyanidin rich extract from french maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial

  • Identification data

    Identifier: PC:1841
    Authors:
    Rosa-M VallsElisabet LlauradóSara Fernández-CastillejoRosa SolàFrancesc PuiggrósLluis ArolaAnna Pedret
    Abstract:
    DOI: 10.1016/j.phymed.2016.08.007 URL: http://www.sciencedirect.com/science/article/pii/S0944711316301490 Filiació URV: SI
  • Others:

    Author, as appears in the article.: Rosa-M Valls; Elisabet Llauradó; Sara Fernández-Castillejo; Rosa Solà; Francesc Puiggrós; Lluis Arola; Anna Pedret
    Department: Bioquímica i Biotecnologia Medicina i Cirurgia
    URV's Author/s: VALLS ZAMORA, ROSA MARIA; LLAURADÓ RIBÉ, ELISABET; FERNÁNDEZ CASTILLEJO, SARA; SOLÀ ALBERICH, ROSA MARIA; PUIGGROS LLAVINÉS, FRANCESC; AROLA FERRER, LUIS MARIA; PEDRET FIGUEROLA, ANNA
    Keywords: Cardiovascular biomarkers Systolic blood pressur HDL-c Low weight Molecular procyanidin
    Abstract: Background Oligopinۚ (OP) is a quantified extract from French Maritime Pine bark (FMPB) with low molecular weight procyanidins. The cardioprotective effects of OP need to be tested in human clinical intervention trials with an appropriate design. Purpose The aim of the present study was to assess the effect of subchronic consumption of OP on cardiovascular disease risk factors such as lipid profile, systolic blood pressure (BP) and oxidized-Low Density Lipoprotein (ox-LDL) in stage-1-hypertensive subjects. Methods Between February 14 and May 31, 2014, eligible subjects were recruited from the outpatient clinics of Hospital Universitari Sant Joan (Reus, Spain). A total of 24 participants (mean age ± DS; 57.36 ± 11.25; 17 men) with stage-1-hypertension who were not receiving BP-lowering medication and LDL cholesterol < 4.88 mmol/l were randomized in a double-blind, placebo-controlled, crossover study. The subjects received 2 capsules/day with 75 mg of OP or placebo for 5-weeks. Results At 5-weeks, compared to the placebo, OP raised High Density Lipoprotein-cholesterol (HDL-c) by 14.06% (p = 0.012) and apolipoprotein A-1 by 8.12% (p = 0.038) and reduced the ratio of apolipoprotein B-100/A-1 by 10.26% (p = 0.046). Moreover, at 5-weeks, compared to the baseline, OP reduced the systolic BP by 6.36 mmHg (p = 0.014), and decreased ox-LDL concentrations by 31.72 U/l (p = 0.015). Conclusion At 5-weeks, the consumption of 150 mg/day of OP improve lipid cardiovascular profile and represents one of the scarce ways to increase HDL-c in stage-1-hypertensive subjects.
    Research group: Unitat de Recerca de Lípids i Arteriosclerosi Grup de Recerca en Nutrigenòmica
    Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: rosamaria.valls@urv.cat
    ISSN: 0944-7113
    Record's date: 2016-09-22
    Last page: 1461
    Journal volume: 23
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0944711316301490
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.phymed.2016.08.007
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    First page: 1451
    Publication Type: Article Artículo Article
  • Keywords:

    Sistema cardiovascular malalties
    Marcadors bioquímics
    Cardiovascular biomarkers
    Systolic blood pressur
    HDL-c
    Low weight
    Molecular procyanidin
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    0944-7113
  • Documents:

  • Cerca a google

    Search to google scholar