Author, as appears in the article.: Siqueira J, Sutton D, García D, Gené J, Thomson P, Wiederhold N, Guarro J
Department: Ciències Mèdiques Bàsiques
URV's Author/s: GARCÍA SÁNCHEZ, DANIA; Joao Paulo Zen SIQUEIRA; Deanna A. SUTTON; GENÉ DÍAZ, JOSEPA; Pamela THOMSON; Nathan WIEDERHOLD; GUARRO ARTIGAS, JOSEP
Keywords: taxonomy Aspergilli Ascomycetes
Abstract: Aspergillus section Versicolores includes species of clinical relevance and many others that have been poorly studied but are occasionally found in clinical samples. The aim of this study was to investigate, using a multilocus phylogenetic approach, the spectrum of species of the section Versicolores and to determine their in vitro antifungal susceptibility. The study was based on a set of 77 clinical isolates from different USA medical centres, which had been previously identified as belonging to this section. The genetic markers used were internal transcribed spacer (ITS), β-tubulin (BenA), calmodulin (CaM), and RNA polymerase II second largest subunit (RPB2), and the drugs tested, following the CLSI guidelines, were amphotericin B (AMB), itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, terbinafine (TBF), and flucytosine (5FC). The most frequent species were Aspergillus sydowii (26 %), Aspergillus creber (22 %), and Aspergillus amoenus (18.2 %), followed by Aspergillus protuberus (13 %), Aspergillus jensenii (10.4 %), and Aspergillus tabacinus (5.2 %); while Aspergillus cvjetkovicii, Aspergillus fructus, Aspergillus puulaauensis, and Aspergillus versicolor were represented by only one isolate each (1.3 %). This is the first time that A. jensenii and A. puulaauensis have been reported from clinical samples. Considering the high number of isolates identified as belonging to this fungal group in this study, its clinical relevance should not be overlooked. Aspergillus versicolor, traditionally considered one of the most common species in this section in a clinical setting, was only rarely recovered in our study. The in vitro antifungal results showed that echinocandins and TBF were the most potent drugs, the azoles showed variable results, AMB was poorly active, and 5FC was the less active.
Research group: Unitat de Micologia i Microbiologia Ambiental
Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1878-6146
Record's date: 2016-11-10
Last page: 1467
Journal volume: 120
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S187861461600043X?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.funbio.2016.02.006
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: 1458
Publication Type: Article Artículo Article
Repositori URV