Articles producció científica> Medicina i Cirurgia

Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial

  • Identification data

    Identifier: PC:2489
    Handle: https://hdl.handle.net/20.500.11797/PC2489
    Authors:
    Rosa-M. VallsMarta FarràsAnna PedretSara Fernández-CastillejoÚrsula CatalánMarta RomeuMontse GiraltGuillermo-T. SáezMontserrat FitóRafael de la TorreMaría-Isabel CovasMaría-José MotilvaRosa SolàLaura Rubió
    Abstract:
    The aim of the present study was to assess whether different functional virgin olive oils (FVOOs) with varying phenolic compounds (PC) could protect the plasmatic fat-soluble vitamins, which in turn could improve the endothelial function. In order to select the optimal phenolic dose in the improvement of ischemic reactive hyperemia (IRH), a dose-response study (n = 12, healthy subjects) was performed and the enrichment of 500 mg PC/kg oil was selected. In a 3-week cross-over sustained study (n = 33 hypercholesterolemic subjects), the consumption of 25 mL/day of two phenol-enriched olive oils (one enriched with its own PC and another combined with thyme PC) increased IRH and plasma concentrations of retinol, β-cryptoxanthin and α-tocopherol, compared to a control virgin olive oil. A positive post-intervention correlation was observed for IRH values and HDL-c, β-cryptoxanthin, lutein and α-tocopherol. Results suggest that preservation of plasmatic fat-soluble vitamins by PC from FVOOS could partially explain the endothelial function benefits.

  • Others:

    Author, as appears in the article.: Rosa-M. Valls; Marta Farràs; Anna Pedret; Sara Fernández-Castillejo ; Úrsula Catalán; Marta Romeu; Montse Giralt; Guillermo-T. Sáez ; Montserrat Fitó; Rafael de la Torre; María-Isabel Covas; María-José Motilva; Rosa Solà; Laura Rubió
    Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
    URV's Author/s: VALLS ZAMORA, ROSA MARIA; PEDRET FIGUEROLA, ANNA; FERNÁNDEZ CASTILLEJO, SARA; CATALÁN SANTOS, ÚRSULA; ROMEU FERRAN, MARTA; GIRALT BATISTA, MONTSERRAT; SOLÀ ALBERICH, ROSA MARIA; RUBIÓ, LAURA
    Keywords: virgin olive oil Phenolic compounds endothelial function
    Abstract: The aim of the present study was to assess whether different functional virgin olive oils (FVOOs) with varying phenolic compounds (PC) could protect the plasmatic fat-soluble vitamins, which in turn could improve the endothelial function. In order to select the optimal phenolic dose in the improvement of ischemic reactive hyperemia (IRH), a dose-response study (n = 12, healthy subjects) was performed and the enrichment of 500 mg PC/kg oil was selected. In a 3-week cross-over sustained study (n = 33 hypercholesterolemic subjects), the consumption of 25 mL/day of two phenol-enriched olive oils (one enriched with its own PC and another combined with thyme PC) increased IRH and plasma concentrations of retinol, β-cryptoxanthin and α-tocopherol, compared to a control virgin olive oil. A positive post-intervention correlation was observed for IRH values and HDL-c, β-cryptoxanthin, lutein and α-tocopherol. Results suggest that preservation of plasmatic fat-soluble vitamins by PC from FVOOS could partially explain the endothelial function benefits.
    Research group: Unitat de Recerca de Lípids i Arteriosclerosi Farmacobiologia Cel.lular
    Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: rosamaria.valls@urv.cat
    ISSN: 1756-4646
    Record's date: 2017-01-19
    Last page: 292
    Journal volume: 28
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S1756464616303607
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.jff.2016.10.032
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: 285
    Publication Type: Article Artículo Article

  • Keywords:

    Funció endotelial
    Fenols
    Oli d'oliva
    virgin olive oil
    Phenolic compounds
    endothelial function
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    1756-4646

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