Highly versatile Pd-thioether-phosphite catalytic systems for asymmetric allylic alkylation

Identifier:  PC:2565

Handle: https://hdl.handle.net/20.500.11797/PC2565

Authors:  Mercè Coll; Oscar Pàmies; Montserrat Diéguez

Abstract:
A Pd-furanoside thioether-phosphite catalytic system that can create new C-C, C-N, and C-O bonds in several substrate types using a wide range of nucleophiles in high yields and enantioselectivities has been identified. Of particular note are the excellent enantioselectivities obtained in the etherification of linear and cyclic substrates. The potential application of the new Pd-thioether-phosphite catalytic systems was also demonstrated by the synthesis of the chiral carbo- and heterocycles.