Author, as appears in the article.: Fernández, E.; Calow, A.D.J; Whiting, A.
Department: Química Física i Inorgànica
URV's Author/s: FERNÁNDEZ GUTIÉRREZ, MARIA ELENA; Calow, A.D.J; Whiting, A.
Keywords: synthesis of fluoxetine
Abstract: We report efficient, catalytic, asymmetric total syntheses of both (R)-Fluoxetine and (S)-Duloxetine from ¿¿¿-unsaturated aldehydes conducting five sequential one pot steps (imine formation / copper mediated ¿-borylation / transimination / reduction / oxidation) followed by the specific ether group formation which deliver to the desired products (R)-Fluoxetine in 45% yield (96% e.e.) and (S)-Duloxetine in 47% yield (94% e.e.)
Research group: Organometàl.lics i Catàlisi Homogènia
Thematic Areas: Chemistry Química Química
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1477-0520
Author identifier: 0000-0001-9025-1791; 0000-0001-7705-6940; 0000-0001-8937-8445
Record's date: 2017-03-17
Last page: 6127
Journal volume: 12
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2014/OB/C4OB01142B#!divAbstract
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1039/C4OB01142B
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
First page: 6121
Publication Type: Article Artículo Article
Repositori URV