Articles producció científicaQuímica Física i Inorgànica

Total synthesis of Fluoxetine & Duloxetine through an in situ imine formation/borylation/transimination and reduction approach

  • Identification data

    Identifier:  PC:2635
    Handle: https://hdl.handle.net/20.500.11797/PC2635
    Authors:  Fernández, E.; Calow, A.D.J; Whiting, A.
    Abstract:
    We report efficient, catalytic, asymmetric total syntheses of both (R)-Fluoxetine and (S)-Duloxetine from ¿¿¿-unsaturated aldehydes conducting five sequential one pot steps (imine formation / copper mediated ¿-borylation / transimination / reduction / oxidation) followed by the specific ether group formation which deliver to the desired products (R)-Fluoxetine in 45% yield (96% e.e.) and (S)-Duloxetine in 47% yield (94% e.e.)

  • Others:

    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2014/OB/C4OB01142B#!divAbstract
    Article's DOI: 10.1039/C4OB01142B
    Journal publication year: 2014
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/acceptedVersion
    Record's date: 2017-03-17
    First page: 6121
    URV's Author/s: FERNÁNDEZ GUTIÉRREZ, MARIA ELENA; Calow, A.D.J; Whiting, A.
    Department: Química Física i Inorgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Article
    Last page: 6127
    ISSN: 1477-0520
    Author, as appears in the article.: Fernández, E.; Calow, A.D.J; Whiting, A.
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Journal volume: 12
    Research group: Organometàl.lics i Catàlisi Homogènia
    Thematic Areas: Chemistry