Articles producció científica> Química Física i Inorgànica

Optofluidic device for the quantification of circulating tumor cells in breast cancer

  • Identification data

    Identifier: PC:2921
    Authors:
    Guerrini, L.Pedrol, E.Garcia-Algar, M.Massons, J.Nazarenus, M.Martínez, J.Rodenas, A.Fernandez-Carrascal, A.Aguiló, M.Estevez, L.G.Calvo, I.Olano-Daza, A.Garcia-Rico, E.Díaz, F.Alvarez-Puebla, R.A.
    Abstract:
    DOI: 10.1038/s41598-017-04033-9 https://www.nature.com/articles/s41598-017-04033-9 Filiació URV: SI
  • Others:

    Author, as appears in the article.: Guerrini, L.; Pedrol, E.; Garcia-Algar, M.; Massons, J.; Nazarenus, M.; Martínez, J.; Rodenas, A.; Fernandez-Carrascal, A.; Aguiló, M.; Estevez, L.G.; Calvo, I.; Olano-Daza, A.; Garcia-Rico, E.; Díaz, F.; Alvarez-Puebla, R.A.
    Department: Química Física i Inorgànica
    URV's Author/s: GUERRINI , LUCA; Pedrol, E.; Garcia-Algar, M.; Massons, J.; Nazarenus, M.; Martínez, J.; RODENAS SEGUI, AIRAN; Fernandez-Carrascal, A.; AGUILÓ DÍAZ, MAGDALENA; Estevez, L.G.; Calvo, I.; Olano-Daza, A.; Garcia-Rico, E.; DÍAZ GONZÁLEZ, FRANCISCO MANUEL; ALVAREZ PUEBLA, RAMON ANGEL
    Abstract: Metastatic cancer patients require a continuous monitoring during the sequential treatment cycles to carefully evaluate their disease evolution. Repetition of biopsies is very invasive and not always feasible. Herein, we design and demonstrate a 3D-flow focusing microfluidic device, where all optics are integrated into the chip, for the fluorescence quantification of CTCs in real samples. To test the chip performance, two cell membrane targets, the epithelial cell adhesion molecule, EpCAM, and the receptor tyrosine-protein kinase, HER2, are selected. The efficiency of the platform is demonstrated on cell lines and in a variety of healthy donors and metastatic-breast cancer patients.
    Research group: Física i Cristal·lografia de Nanomaterials Grupo de Plasmonica y Ultradetección Física i Cristal.lografia de Materials
    Thematic Areas: Chemistry Química Química
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2045-2322
    Author identifier: 0000-0002-2925-1562; ; ; ; ; ; ; ; 0000-0001-6130-9579; ; ; ; ; 0000-0003-4581-4967; 0000-0003-4770-5756
    Record's date: 2017-10-20
    Journal volume: 7
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-017-04033-9
    Funding program: altres; ICREA academia award 2010; ICREA; ICREA-02 altres; Grups consolidats Generalitat de Catalunya; SGR; 2014SGR480 altres; Grups consolidats Generalitat de Catalunya; SGR; 2014SGR1358 plan; Ministerio de Economia y Competitividad; CTQ2014; CTQ2014-59808R plan; Ministerio de Economia y Competitividad; TEC; TEC2014- 55948-R plan; Ministerio de Economia y Competitividad; MAT; MAT2013-47395-C4-4-R
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1038/s41598-017-04033-9
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: 3677
    Publication Type: Article Artículo Article
  • Keywords:

    Mama--Càncer
    Marcadors tumorals
    Chemistry
    Química
    Química
    2045-2322
  • Documents:

  • Cerca a google

    Search to google scholar