Articles producció científica> Medicina i Cirurgia

A lower baseline CD4/CD8 T-cell ratio is independently associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects

  • Identification data

    Identifier: PC:2956
    Authors:
    Vidal, F.Rosado-Sánchez, I.Herrero-Fernández, I.Álvarez-Ríos, A.I.Genebat, M.Abad-Carrillo, M.A.Ruiz-Mateos, E.Pulido, F.González-García, J.Montero, M.Bernal-Morell, E.Leal, M.Pacheco, Y.M.
    Abstract:
    We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.
  • Others:

    Author, as appears in the article.: Vidal, F.; Rosado-Sánchez, I.; Herrero-Fernández, I.; Álvarez-Ríos, A.I.; Genebat, M. ; Abad-Carrillo, M.A.; Ruiz-Mateos, E.; Pulido, F.; González-García, J.; Montero, M.; Bernal-Morell, E.; Leal, M.; Pacheco, Y.M.
    Department: Medicina i Cirurgia
    URV's Author/s: VIDAL MARSAL, FRANCISCO; Rosado-Sánchez, I.; Herrero-Fernández, I.; Álvarez-Ríos, A.I.; Genebat, M. ; Abad-Carrillo, M.A.; Ruiz-Mateos, E.; Pulido, F.; González-García, J.; Montero, M.; Bernal-Morell, E.; Leal, M.; Pacheco, Y.M.
    Keywords: Delayed cART CD4/CD8 ratio antiretroviral therapy
    Abstract: We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.
    Research group: Grup de Recerca Biomèdica HJ23
    Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0066-4804
    Author identifier: 0000-0002-6692-6186
    Record's date: 2017-11-30
    Journal volume: 61
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://aac.asm.org/content/61/8/e00605-17.long
    Funding program: plan; Ministerio de Sanidad, Servicios Sociales e Igualdad; ISCIII; RD12/0017/0037 altres; Instituto de Salud Carlos III; ISCIII; RD12/0017/0018 plan; Ministerio de Sanidad, Servicios Sociales e Igualdad; ISCIII; RD06/0006/0035 altres; Instituto de Salud Carlos III; ISCIII; PI14/01693 altres; Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía; FEDER; CTS2593
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1128/AAC.00605-17
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: e00605
    Publication Type: Article Artículo Article
  • Keywords:

    VIH (Virus)
    Resposta immunitària
    Antiretrovirals
    Delayed cART
    CD4/CD8 ratio
    antiretroviral therapy
    Health sciences
    Ciencias de la salud
    Ciències de la salut
    0066-4804
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