Repositori URV

Identifier: PC:2956

Handle: https://hdl.handle.net/20.500.11797/PC2956

Authors:
Vidal, F.Rosado-Sánchez, I.Herrero-Fernández, I.Álvarez-Ríos, A.I.Genebat, M.Abad-Carrillo, M.A.Ruiz-Mateos, E.Pulido, F.González-García, J.Montero, M.Bernal-Morell, E.Leal, M.Pacheco, Y.M.

Abstract:
We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.