Articles producció científica> Medicina i Cirurgia

Parallel evolution of circulating FABP4 and NT-proBNP in heart failure patients.

  • Identification data

    Identifier: PC:554
    Handle: https://hdl.handle.net/20.500.11797/PC554
    Authors:
    Masana, L.Bardají, A.Bonet, G.Lázaro, I.Valdovinos, P.Cabré, A.
    Abstract:
    Abstract Background: Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases. In vitro, FABP4 has exhibited cardiodepressant activity by suppressing cardiomyocyte contraction. We have explored the relationship between FABP4 and the N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) as a clinical parameter of heart failure (HF). Methods: We included 179 stable HF patients who were referred to a specialized HF unit, 108 of whom were prospectively followed for up to 6 months. A group of 163 non-HF patients attending a CV risk unit was used as the non-HF control group for the FABP4 comparisons. Results: In the HF patients, FABP4 and NT-proBNP were assayed, along with a clinical and functional assessment of the heart at baseline and after 6 months of specialized monitoring. The FABP4 levels were higher in the patients with HF than in the non-HF high CV risk control group (p<0.001). The FABP4 levels were associated with the NT-proBNP levels in patients with HF (r=0.601, p<0.001), and this association was stronger in the diabetic patients. FABP4 was also associated with heart rate and the results of the 6-minute walk test. After the follow-up period, FABP4 decreased in parallel to NT-proBNP and to the clinical parameters of HF. Conclusions: FABP4 is associated with the clinical manifestations and biomarkers of HF. It exhibits a parallel evolution with the circulating levels of NT-proBNP in HF patients. Keywords: FABP4, Heart failure, NT-proBNP, Obesity, Diabetes

  • Others:

    Author, as appears in the article.: Masana, L. Bardají, A. Bonet, G. Lázaro, I. Valdovinos, P. Cabré, A.
    Department: Medicina i Cirurgia
    e-ISSN: 1475-2840
    URV's Author/s: Anna Cabré, Pilar Valdovinos, Iolanda Lázaro, Gil Bonet, Alfredo Bardají and Lluís Masana
    Abstract: Abstract Background: Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases. In vitro, FABP4 has exhibited cardiodepressant activity by suppressing cardiomyocyte contraction. We have explored the relationship between FABP4 and the N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) as a clinical parameter of heart failure (HF). Methods: We included 179 stable HF patients who were referred to a specialized HF unit, 108 of whom were prospectively followed for up to 6 months. A group of 163 non-HF patients attending a CV risk unit was used as the non-HF control group for the FABP4 comparisons. Results: In the HF patients, FABP4 and NT-proBNP were assayed, along with a clinical and functional assessment of the heart at baseline and after 6 months of specialized monitoring. The FABP4 levels were higher in the patients with HF than in the non-HF high CV risk control group (p<0.001). The FABP4 levels were associated with the NT-proBNP levels in patients with HF (r=0.601, p<0.001), and this association was stronger in the diabetic patients. FABP4 was also associated with heart rate and the results of the 6-minute walk test. After the follow-up period, FABP4 decreased in parallel to NT-proBNP and to the clinical parameters of HF. Conclusions: FABP4 is associated with the clinical manifestations and biomarkers of HF. It exhibits a parallel evolution with the circulating levels of NT-proBNP in HF patients. Keywords: FABP4, Heart failure, NT-proBNP, Obesity, Diabetes
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Journal volume: 12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: http://www.cardiab.com/content/12/1/72
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: https://doi.org/10.1186/1475-2840-12-72
    Entity: Universitat Rovira i Virgili.
    Journal publication year: 2013
    First page: 72