Author, as appears in the article.: Schuhmacher, Marta; Fabrega, Francesc; Kumar, Vikas; Garcia, Francisco; Nadal, Marti; Domingo, Jose L
Department: Enginyeria Química Ciències Mèdiques Bàsiques
URV's Author/s: Domingo Roig, José Luis / FABREGA BONADONA, FRANCESC / GARCÍA ESTARLICH, FRANCISCO / García Sayago, Francisco / Kumar, Vikas / Nadal Lomas, Martí / Schuhmacher Ansuategui, Marta
Keywords: Temporal trend Physiologically-based pharmacokinetic (pbpk) model Pcdd/fs Pbpk model Hazardous waste incinerator Adipose tissue pcdd/fs pbpk model hazardous waste incinerator adipose tissue
Abstract: This study was aimed at determining the concentrations of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in 15 samples of adipose tissue from subjects who had been living in the vicinity of a hazardous waste incinerator (HWI). The results were compared with levels obtained in previous surveys carried out in 1998 (baseline study), 2002 and 2007. The current (2013) concentrations of PCDD/Fs in adipose tissue ranged from 2.8 to 46.3 pg WHO-TEQ/g fat (mean and median concentrations: 11.5 and 7.4 pg WHO-TEQ/g fat, respectively), being significantly lower (64%) than those observed in 1998. In contrast, no significant differences in the mean PCDD/F concentrations were noted in the period 2002-2013. The significant decrease of the PCDD/F content in fat, also noted in other biological monitors such as plasma and breast milk, is in agreement with the reduction in the dietary intake of PCDD/Fs found in the same area of study. Similarly to other investigations across Europe, an increase of PCDD/F levels in adipose tissue in relation to age was observed, while no significant differences were noted according to gender. A multicompartmental physiologically-based pharmacokinetic (PBPK) model was also applied to estimate the levels of PCDD/Fs in adipose tissue. When comparing the modeled and experimental concentrations of PCDD/Fs in that tissue, very similar values were obtained for the four surveys, which indicates this can be a reliable tool to predict the internal dose of PCDD/Fs.Copyright © 2014 Elsevier Ltd. All rights reserved.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Medicina iii Medicina ii Medicina i Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Engenharias iv Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01604120
Author's mail: vikas.kumar@urv.cat francisco.garcia@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat marta.schuhmacher@urv.cat
Author identifier: 0000-0002-9795-5967 0000-0003-0594-8370 0000-0001-6647-9470 0000-0002-0217-4827 0000-0003-4381-2490
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Environment International. 73 150-157
APA: Schuhmacher, Marta; Fabrega, Francesc; Kumar, Vikas; Garcia, Francisco; Nadal, Marti; Domingo, Jose L (2014). A PBPK model to estimate PCDD/F levels in adipose tissue: Comparison with experimental values of residents near a hazardous waste incinerator. Environment International, 73(), 150-157. DOI: 10.1016/j.envint.2014.07.020
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications
Repositori URV