Author, as appears in the article.: Schuhmacher, Marta; Fabrega, Francesc; Kumar, Vikas; Garcia, Francisco; Nadal, Marti; Domingo, Jose L
Department: Enginyeria Química; Ciències Mèdiques Bàsiques
URV's Author/s: Domingo Roig, José Luis / FABREGA BONADONA, FRANCESC / GARCÍA ESTARLICH, FRANCISCO / García Sayago, Francisco / Kumar, Vikas / Nadal Lomas, Martí / Schuhmacher Ansuategui, Marta
Keywords: Temporal trend; Polychlorinated dibenzodioxins; Physiologically-based pharmacokinetic (pbpk) model; Pharmacokinetics; Pcdd/fs; Pbpk model; Models, biological; Milk, human; Middle aged; Male; Incineration; Humans; Hazardous waste incinerator; Hazardous waste; Female; Dibenzofurans, polychlorinated; Benzofurans; Air pollutants; Aged; Adult; Adipose tissue; pcdd/fs; pbpk model; hazardous waste incinerator; adipose tissue
Abstract: This study was aimed at determining the concentrations of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in 15 samples of adipose tissue from subjects who had been living in the vicinity of a hazardous waste incinerator (HWI). The results were compared with levels obtained in previous surveys carried out in 1998 (baseline study), 2002 and 2007. The current (2013) concentrations of PCDD/Fs in adipose tissue ranged from 2.8 to 46.3 pg WHO-TEQ/g fat (mean and median concentrations: 11.5 and 7.4 pg WHO-TEQ/g fat, respectively), being significantly lower (64%) than those observed in 1998. In contrast, no significant differences in the mean PCDD/F concentrations were noted in the period 2002-2013. The significant decrease of the PCDD/F content in fat, also noted in other biological monitors such as plasma and breast milk, is in agreement with the reduction in the dietary intake of PCDD/Fs found in the same area of study. Similarly to other investigations across Europe, an increase of PCDD/F levels in adipose tissue in relation to age was observed, while no significant differences were noted according to gender. A multicompartmental physiologically-based pharmacokinetic (PBPK) model was also applied to estimate the levels of PCDD/Fs in adipose tissue. When comparing the modeled and experimental concentrations of PCDD/Fs in that tissue, very similar values were obtained for the four surveys, which indicates this can be a reliable tool to predict the internal dose of PCDD/Fs.Copyright © 2014 Elsevier Ltd. All rights reserved.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Geociências; General medicine; General environmental science; Farmacia; Environmental sciences; Environmental science (miscellaneous); Environmental science (all); Engenharias iv; Engenharias ii; Engenharias i; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Biotecnología; Biodiversidade; Astronomia / física; Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 01604120
Author's mail: vikas.kumar@urv.cat; francisco.garcia@urv.cat; joseluis.domingo@urv.cat; marti.nadal@urv.cat; marta.schuhmacher@urv.cat
Record's date: 2025-12-09
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0160412014002414?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Environment International. 73 150-157
APA: Schuhmacher, Marta; Fabrega, Francesc; Kumar, Vikas; Garcia, Francisco; Nadal, Marti; Domingo, Jose L (2014). A PBPK model to estimate PCDD/F levels in adipose tissue: Comparison with experimental values of residents near a hazardous waste incinerator. Environment International, 73(), 150-157. DOI: 10.1016/j.envint.2014.07.020
Article's DOI: 10.1016/j.envint.2014.07.020
Entity: Universitat Rovira i Virgili
Journal publication year: 2014-12-01
Publication Type: Journal Publications
Repositori URV