Articles producció científica> Bioquímica i Biotecnologia

Dairy product consumption and risk of colorectal cancer in an older Mediterranean population at high cardiovascular risk.

  • Identification data

    Identifier: imarina:3423196
    Authors:
    Barrubés L, Babio N, Mena-Sánchez G, Toledo E, Ramírez-Sabio JB, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Pintó X, Martínez-González MÁ, Sorlí JV, Basora J, Salas-Salvadó J, PREvención con DIeta MEDiterránea Study Investigators
    Abstract:
    © 2018 UICC. Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137-item food-frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow-up. During a median [interquartile range] follow-up of 6.0 [4.4-7.3] years, we documented 101 incident CRC cases. In the multivariable-adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low-fat milk consumption were 0.55 (95% CI: 0.31-0.99; p-trend=0.037) and 0.54 (95% CI: 0.32-0.92; p-trend=0.022), respectively. No significant associations with other dairy products (whole-fat and low-fat dairy products; total, low-fat and whole-fat yogurt; cheese; total, low-fat and whole-fat milk; concentrated full-fat dairy products, sugar-enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low-fat milk was significantly associated with a reduced CRC risk.
  • Others:

    Author, as appears in the article.: Barrubés L, Babio N, Mena-Sánchez G, Toledo E, Ramírez-Sabio JB, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Pintó X, Martínez-González MÁ, Sorlí JV, Basora J, Salas-Salvadó J, PREvención con DIeta MEDiterránea Study Investigators
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Barrubés Piñol, Laura / Basora Gallisa, Josep / MENA SÁNCHEZ, GUILLERMO / Salas Salvadó, Jorge
    Keywords: Predimed study Milk Mediterranean diet Dairy products Colorectal cancer predimed study mediterranean diet dairy products colorectal cancer
    Abstract: © 2018 UICC. Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137-item food-frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow-up. During a median [interquartile range] follow-up of 6.0 [4.4-7.3] years, we documented 101 incident CRC cases. In the multivariable-adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low-fat milk consumption were 0.55 (95% CI: 0.31-0.99; p-trend=0.037) and 0.54 (95% CI: 0.32-0.92; p-trend=0.022), respectively. No significant associations with other dairy products (whole-fat and low-fat dairy products; total, low-fat and whole-fat yogurt; cheese; total, low-fat and whole-fat milk; concentrated full-fat dairy products, sugar-enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low-fat milk was significantly associated with a reduced CRC risk.
    Thematic Areas: Saúde coletiva Química Oncology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cancer research Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00207136
    Author's mail: josep.basora@urv.cat josep.basora@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.31540
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Cancer. 143 (6): 1356-1366
    APA: Barrubés L, Babio N, Mena-Sánchez G, Toledo E, Ramírez-Sabio JB, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Pintó X, M (2018). Dairy product consumption and risk of colorectal cancer in an older Mediterranean population at high cardiovascular risk.. International Journal Of Cancer, 143(6), 1356-1366. DOI: 10.1002/ijc.31540
    Article's DOI: 10.1002/ijc.31540
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Cancer Research,Oncology
    Predimed study
    Milk
    Mediterranean diet
    Dairy products
    Colorectal cancer
    predimed study
    mediterranean diet
    dairy products
    colorectal cancer
    Saúde coletiva
    Química
    Oncology
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Cancer research
    Biotecnología
    Biodiversidade
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