Author, as appears in the article.: Barrubés L, Babio N, Mena-Sánchez G, Toledo E, Ramírez-Sabio JB, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Pintó X, Martínez-González MÁ, Sorlí JV, Basora J, Salas-Salvadó J, PREvención con DIeta MEDiterránea Study Investigators
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Barrubés Piñol, Laura / Basora Gallisa, Josep / MENA SÁNCHEZ, GUILLERMO / Salas Salvadó, Jorge
Keywords: Predimed study Milk Mediterranean diet Dairy products Colorectal cancer predimed study mediterranean diet dairy products colorectal cancer
Abstract: © 2018 UICC. Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137-item food-frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow-up. During a median [interquartile range] follow-up of 6.0 [4.4-7.3] years, we documented 101 incident CRC cases. In the multivariable-adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low-fat milk consumption were 0.55 (95% CI: 0.31-0.99; p-trend=0.037) and 0.54 (95% CI: 0.32-0.92; p-trend=0.022), respectively. No significant associations with other dairy products (whole-fat and low-fat dairy products; total, low-fat and whole-fat yogurt; cheese; total, low-fat and whole-fat milk; concentrated full-fat dairy products, sugar-enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low-fat milk was significantly associated with a reduced CRC risk.
Thematic Areas: Saúde coletiva Química Oncology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cancer research Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00207136
Author's mail: josep.basora@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat josep.basora@urv.cat
Author identifier: 0000-0003-3527-5277 0000-0003-2700-7459
Record's date: 2024-05-23
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijc.31540
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Cancer. 143 (6): 1356-1366
APA: Barrubés L, Babio N, Mena-Sánchez G, Toledo E, Ramírez-Sabio JB, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Pintó X, M (2018). Dairy product consumption and risk of colorectal cancer in an older Mediterranean population at high cardiovascular risk.. International Journal Of Cancer, 143(6), 1356-1366. DOI: 10.1002/ijc.31540
Article's DOI: 10.1002/ijc.31540
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV