Articles producció científica> Psicologia

Association study of monoamine oxidase-A gene promoter polymorphism (MAOA-uVNTR) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents

  • Identification data

    Identifier: imarina:3642034
    Authors:
    Voltas N, Aparicio E, Arija V, Canals J.
    Abstract:
    The polymorphism upstream of the gene for monoamine oxidase A (MAOA-uVNTR) is reported to be an important enzyme involved in human physiology and behavior. With a sample of 228 early-adolescents from a community sample (143 girls) and adjusting for environmental variables, we examined the influence of MAOA-uVNTR alleles on the scores obtained in the Screen for Childhood Anxiety and Related Emotional Disorders and in the Child Symptom Inventory-4. Our results showed that girls with the high-activity MAOA allele had higher scores for generalized and total anxiety than their low-activity peers, whereas boys with the low-activity allele had higher social phobia scores than boys with the high-activity allele. Results for conduct disorder symptoms did not show a significant relationship between the MAOA alleles and the presence of these symptoms. Our findings support a possible association, depending on gender, between the MAOA-uVNTR polymorphism and psychopathological disorders such as anxiety, which affects high rates of children and adolescents.
  • Others:

    Author, as appears in the article.: Voltas N, Aparicio E, Arija V, Canals J.
    Department: Ciències Mèdiques Bàsiques Psicologia
    URV's Author/s: Aparicio Llopis, Estefania / Arija Val, Maria Victoria / Canals Sans, Josefa / Voltas Moreso, Núria
    Keywords: Psychopathology Maoa-uvntr Gender Anxiety Adolescents maoa-uvntr gender anxiety adolescents
    Abstract: The polymorphism upstream of the gene for monoamine oxidase A (MAOA-uVNTR) is reported to be an important enzyme involved in human physiology and behavior. With a sample of 228 early-adolescents from a community sample (143 girls) and adjusting for environmental variables, we examined the influence of MAOA-uVNTR alleles on the scores obtained in the Screen for Childhood Anxiety and Related Emotional Disorders and in the Child Symptom Inventory-4. Our results showed that girls with the high-activity MAOA allele had higher scores for generalized and total anxiety than their low-activity peers, whereas boys with the low-activity allele had higher social phobia scores than boys with the high-activity allele. Results for conduct disorder symptoms did not show a significant relationship between the MAOA alleles and the presence of these symptoms. Our findings support a possible association, depending on gender, between the MAOA-uVNTR polymorphism and psychopathological disorders such as anxiety, which affects high rates of children and adolescents.
    Thematic Areas: Saúde coletiva Psychology, clinical Psychology Psychiatry and mental health Psychiatry Psicología Nutrição Medicina ii Medicina i General medicine Educação física Clinical psychology Ciencias sociales Ciências biológicas ii
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nuria.voltas@urv.cat josefa.canals@urv.cat victoria.arija@urv.cat
    Author identifier: 0000-0001-8855-0282 0000-0002-6209-9558 0000-0002-1758-0975
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0887618515000274?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Anxiety Disorders. 31 65-72
    APA: Voltas N, Aparicio E, Arija V, Canals J. (2015). Association study of monoamine oxidase-A gene promoter polymorphism (MAOA-uVNTR) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents. Journal Of Anxiety Disorders, 31(), 65-72. DOI: 10.1016/j.janxdis.2015.02.004
    Article's DOI: 10.1016/j.janxdis.2015.02.004
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2015
    Publication Type: Journal Publications
  • Keywords:

    Clinical Psychology,Psychiatry,Psychiatry and Mental Health,Psychology, Clinical
    Psychopathology
    Maoa-uvntr
    Gender
    Anxiety
    Adolescents
    maoa-uvntr
    gender
    anxiety
    adolescents
    Saúde coletiva
    Psychology, clinical
    Psychology
    Psychiatry and mental health
    Psychiatry
    Psicología
    Nutrição
    Medicina ii
    Medicina i
    General medicine
    Educação física
    Clinical psychology
    Ciencias sociales
    Ciências biológicas ii
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