Asymmetric metal free B-boration of a,B-unsaturated imines assisted by (S)-MeBoPhoz

Identifier:  imarina:3653867

Handle: https://hdl.handle.net/20.500.11797/imarina3653867

Authors:  La Cascia, E; Sanz, X; Bo, C; Whiting, A; Fernandez, E

Abstract:
The adduct [MeO → Bpin-Bpin]- efficiently mediates the β-boration of α,β-unsaturated imines formed in situ. The use of chiral phosphines as additives, and in particular the chiral phosphine (S)-MeBoPhoz, enables the catalytic asymmetric reaction to proceed with higher enantioselectivity than the analogue copper(i) mediated reaction.