Broad scope gold(i)-catalysed polyenyne cyclisations for the formation of up to four carbon-carbon bonds

Identifier:  imarina:3658067

Handle: https://hdl.handle.net/20.500.11797/imarina3658067

Authors:  Rong, ZT; Echavarren, AM

Abstract:
The polycyclisation of polyenynes catalyzed by gold(i) has been extended for the first time to the simultaneous formation of up to four carbon-carbon bonds, leading to steroid-like molecules with high stereoselectivity in a single step with low catalyst loadings. In addition to terminal alkynes, bromoalkynes can also be used as initiators of polyene cyclisations, giving rise to synthetically useful cyclic bromoalkenes.