Articles producció científicaMedicina i Cirurgia

Long-Term Anticoagulant Therapy of Patients with Venous Thromboembolism. What Are the Practices?

  • Identification data

    Identifier:  imarina:4681106
    Handle: https://hdl.handle.net/20.500.11797/imarina4681106
    Authors:  Mahe, Isabelle; Sterpu, Raluca; Bertoletti, Laurent; Lopez-Jimenez, Luciano; Joan, Meritxell Mellado; Trujillo-Santos, Javier; Ballaz, Aitor; Hernandez Blasco, Luis Manuel; Javier Marchena, Pablo; Monreal, Manuel
    Abstract:
    Current guidelines of antithrombotic therapy suggest early initiation of vitamin K antagonists (VKA) in non-cancer patients with venous thromboembolism (VTE), and long-term therapy with low-molecular weight heparin (LMWH) for those with cancer. We used data from RIETE (international registry of patients with VTE) to report the use of long-term anticoagulant therapy over time and to identify predictors of anticoagulant choice (regarding international guidelines) in patients with- and without cancer. Among 35,280 patients without cancer, 82% received long-term VKA (but 17% started after the first week). Among 4,378 patients with cancer, 66% received long term LMWH as monotherapy. In patients without cancer, recent bleeding (odds ratio [OR] 2.70, 95% CI 2.26-3.23), age >70 years (OR 1.15, 95% CI 1.06-1.24), immobility (OR 2.06, 95% CI 1.93-2.19), renal insufficiency (OR 2.42, 95% CI 2.15-2.71) and anemia (OR 1.75, 95% CI 1.65-1.87) predicted poor adherence to guidelines. In those with cancer, anemia (OR 1.83, 95% CI 1.64-2.06), immobility (OR 1.51, 95% CI 1.30-1.76) and metastases (OR 3.22, 95% CI 2.87-3.61) predicted long-term LMWH therapy. In conclusion, we report practices of VTE therapy in real life and found that a significant proportion of patients did not receive the recommended treatment. The perceived increased risk for bleeding has an impact on anticoagulant treatment decision.

  • Others:

    Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128741
    APA: Mahe, Isabelle; Sterpu, Raluca; Bertoletti, Laurent; Lopez-Jimenez, Luciano; Joan, Meritxell Mellado; Trujillo-Santos, Javier; Ballaz, Aitor; Hernande (2015). Long-Term Anticoagulant Therapy of Patients with Venous Thromboembolism. What Are the Practices?. Plos One, 10(6), e0128741-. DOI: 10.1371/journal.pone.0128741
    Paper original source: Plos One. 10 (6): e0128741-
    Article's DOI: 10.1371/journal.pone.0128741
    Journal publication year: 2015
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2025-02-24
    URV's Author/s: Porras Ledantes, Jose Antonio
    Department: Medicina i Cirurgia
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Mahe, Isabelle; Sterpu, Raluca; Bertoletti, Laurent; Lopez-Jimenez, Luciano; Joan, Meritxell Mellado; Trujillo-Santos, Javier; Ballaz, Aitor; Hernandez Blasco, Luis Manuel; Javier Marchena, Pablo; Monreal, Manuel
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Zootecnia / recursos pesqueiros, Sociology, Sociología, Serviço social, Saúde coletiva, Química, Psychology, Psicología, Planejamento urbano e regional / demografia, Odontología, Nutrição, Multidisciplinary sciences, Multidisciplinary, Medicine (miscellaneous), Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Materiais, Matemática / probabilidade e estatística, Linguística e literatura, Letras / linguística, Interdisciplinary research in the social sciences, Interdisciplinar, Human geography and urban studies, History & philosophy of science, Historia, Geografía, Geociências, General medicine, General biochemistry,genetics and molecular biology, General agricultural and biological sciences, Farmacia, Environmental studies, Ensino, Engenharias iv, Engenharias iii, Engenharias ii, Engenharias i, Enfermagem, Educação física, Educação, Economia, Direito, Demography, Comunicação e informação, Ciências sociais aplicadas i, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Ciência política e relações internacionais, Ciência de alimentos, Ciência da computação, Biotecnología, Biology, Biodiversidade, Biochemistry, genetics and molecular biology (miscellaneous), Astronomia / física, Arquitetura, urbanismo e design, Archaeology, Antropologia / arqueologia, Anthropology, Agricultural and biological sciences (miscellaneous), Administração, ciências contábeis e turismo, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: joseantonio.porras@urv.cat

  • Keywords:

    Long-term care
    Agricultural and Biological Sciences (Miscellaneous)
    Biochemistry
    Genetics and Molecular Biology (Miscellaneous)
    Biology
    Medicine (Miscellaneous)
    Multidisciplinary
    Multidisciplinary Sciences
    Zootecnia / recursos pesqueiros
    Sociology
    Sociología
    Serviço social
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinary research in the social sciences
    Interdisciplinar
    Human geography and urban studies
    History & philosophy of science
    Historia
    Geografía
    Geociências
    General medicine
    General biochemistry
    genetics and molecular biology
    General agricultural and biological sciences
    Farmacia
    Environmental studies
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Economia
    Direito
    Demography
    Comunicação e informação
    Ciências sociais aplicadas i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência política e relações internacionais
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Arquitetura
    urbanismo e design
    Archaeology
    Antropologia / arqueologia
    Anthropology
    Administração
    ciências contábeis e turismo
    Administração pública e de empresas

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