Author, as appears in the article.: Vila-Corcoles A, Bejarano-Romero F, Salsench E, Ochoa-Gondar O, de Diego C, Gomez-Bertomeu F, Raga-Luria X, Cliville-Guasch X, Arija V

Department: Ciències Mèdiques Bàsiques

e-ISSN: 1471-2334

URV's Author/s: Arija Val, Maria Victoria

Keywords: Susceptibility Surveillance Spain Pneumococcal pneumonia Penicillin resistance Mortality Metaanalysis Infection Antimicrobial resistance

Abstract: Background: Pneumococcal diseases remain a major cause of morbidity and mortality worldwide. Updated data on drug-resistance from different populations may be important to recognize changes in disease patterns. This study assessed current levels of penicilin resistance among Streptococcus Pneumoniae causing pneumonia in Spanish middle age and older adults. Methods: Antimicrobial susceptibility was tested for 104 consecutive isolates of Streptococcus pneumoniae recovered from patients 50 years or older with radiographically confirmed pneumonia in the region of Tarragona (Spain) between 2002 and 2007. According to the minimum inhibitory concentration of tested antimicrobials (penicillin, erythromycin, cefotaxime and levofloxacin) strains were classified as susceptible or resistant. Antimicrobial resistance was determined for early cases (2002-2004) and contemporary cases (2005-2007). Results: Twenty-seven (25.9%) were penicillin-resistant strains (19 strains with intermediate resistance and 8 strains with high resistance). Penicillin-resistance was higher in 2002-2004 than in 2005-2007 (39.5% vs 18.2%, p = 0.017). Of 27 penicillin-resistant strains, 10 (37%) were resistant to erythromycin, 8 (29.6%) to cefotaxime, 2 (7.4%) to levofloxacin, and 4 (14.8%) were identified as multidrug resistant. Case-fatality rate was higher among those patients who had an infection caused by any penicillin susceptible strain (16.9%) than in those with infections due to penicillin-resistant strains. Conclusion: Resistance to penicillin among Streptococcus pneumoniae remains high, but such resistance does not result in increased mortality in patients with pneumococcal pneumonia.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias i Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: victoria.arija@urv.cat

Author identifier: 0000-0002-1758-0975

Record's date: 2023-02-18

Journal volume: 9

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-9-36

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Bmc Infectious Diseases. 9

APA: Vila-Corcoles A, Bejarano-Romero F, Salsench E, Ochoa-Gondar O, de Diego C, Gomez-Bertomeu F, Raga-Luria X, Cliville-Guasch X, Arija V (2009). Drug-resistance in Streptococcus pneumoniae isolates among Spanish middle aged and older adults with community-acquired pneumonia. Bmc Infectious Diseases, 9(), -. DOI: 10.1186/1471-2334-9-36

Article's DOI: 10.1186/1471-2334-9-36

Entity: Universitat Rovira i Virgili

Journal publication year: 2009

Publication Type: Journal Publications