Articles producció científica> Ciències Mèdiques Bàsiques

Drug-resistance in Streptococcus pneumoniae isolates among Spanish middle aged and older adults with community-acquired pneumonia

  • Identification data

    Identifier: imarina:5122840
    Authors:
    Vila-Corcoles A, Bejarano-Romero F, Salsench E, Ochoa-Gondar O, de Diego C, Gomez-Bertomeu F, Raga-Luria X, Cliville-Guasch X, Arija V
    Abstract:
    Background: Pneumococcal diseases remain a major cause of morbidity and mortality worldwide. Updated data on drug-resistance from different populations may be important to recognize changes in disease patterns. This study assessed current levels of penicilin resistance among Streptococcus Pneumoniae causing pneumonia in Spanish middle age and older adults. Methods: Antimicrobial susceptibility was tested for 104 consecutive isolates of Streptococcus pneumoniae recovered from patients 50 years or older with radiographically confirmed pneumonia in the region of Tarragona (Spain) between 2002 and 2007. According to the minimum inhibitory concentration of tested antimicrobials (penicillin, erythromycin, cefotaxime and levofloxacin) strains were classified as susceptible or resistant. Antimicrobial resistance was determined for early cases (2002-2004) and contemporary cases (2005-2007). Results: Twenty-seven (25.9%) were penicillin-resistant strains (19 strains with intermediate resistance and 8 strains with high resistance). Penicillin-resistance was higher in 2002-2004 than in 2005-2007 (39.5% vs 18.2%, p = 0.017). Of 27 penicillin-resistant strains, 10 (37%) were resistant to erythromycin, 8 (29.6%) to cefotaxime, 2 (7.4%) to levofloxacin, and 4 (14.8%) were identified as multidrug resistant. Case-fatality rate was higher among those patients who had an infection caused by any penicillin susceptible strain (16.9%) than in those with infections due to penicillin-resistant strains. Conclusion: Resistance to penicillin among Streptococcus pneumoniae remains high, but such resistance does not result in increased mortality in patients with pneumococcal pneumonia.
  • Others:

    Author, as appears in the article.: Vila-Corcoles A, Bejarano-Romero F, Salsench E, Ochoa-Gondar O, de Diego C, Gomez-Bertomeu F, Raga-Luria X, Cliville-Guasch X, Arija V
    Department: Ciències Mèdiques Bàsiques
    e-ISSN: 1471-2334
    URV's Author/s: Arija Val, Maria Victoria
    Keywords: Susceptibility Surveillance Spain Pneumococcal pneumonia Penicillin resistance Mortality Metaanalysis Infection Antimicrobial resistance
    Abstract: Background: Pneumococcal diseases remain a major cause of morbidity and mortality worldwide. Updated data on drug-resistance from different populations may be important to recognize changes in disease patterns. This study assessed current levels of penicilin resistance among Streptococcus Pneumoniae causing pneumonia in Spanish middle age and older adults. Methods: Antimicrobial susceptibility was tested for 104 consecutive isolates of Streptococcus pneumoniae recovered from patients 50 years or older with radiographically confirmed pneumonia in the region of Tarragona (Spain) between 2002 and 2007. According to the minimum inhibitory concentration of tested antimicrobials (penicillin, erythromycin, cefotaxime and levofloxacin) strains were classified as susceptible or resistant. Antimicrobial resistance was determined for early cases (2002-2004) and contemporary cases (2005-2007). Results: Twenty-seven (25.9%) were penicillin-resistant strains (19 strains with intermediate resistance and 8 strains with high resistance). Penicillin-resistance was higher in 2002-2004 than in 2005-2007 (39.5% vs 18.2%, p = 0.017). Of 27 penicillin-resistant strains, 10 (37%) were resistant to erythromycin, 8 (29.6%) to cefotaxime, 2 (7.4%) to levofloxacin, and 4 (14.8%) were identified as multidrug resistant. Case-fatality rate was higher among those patients who had an infection caused by any penicillin susceptible strain (16.9%) than in those with infections due to penicillin-resistant strains. Conclusion: Resistance to penicillin among Streptococcus pneumoniae remains high, but such resistance does not result in increased mortality in patients with pneumococcal pneumonia.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias i Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: victoria.arija@urv.cat
    Author identifier: 0000-0002-1758-0975
    Record's date: 2023-02-18
    Journal volume: 9
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-9-36
    Papper original source: Bmc Infectious Diseases. 9
    APA: Vila-Corcoles A, Bejarano-Romero F, Salsench E, Ochoa-Gondar O, de Diego C, Gomez-Bertomeu F, Raga-Luria X, Cliville-Guasch X, Arija V (2009). Drug-resistance in Streptococcus pneumoniae isolates among Spanish middle aged and older adults with community-acquired pneumonia. Bmc Infectious Diseases, 9(), -. DOI: 10.1186/1471-2334-9-36
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1186/1471-2334-9-36
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2009
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases
    Susceptibility
    Surveillance
    Spain
    Pneumococcal pneumonia
    Penicillin resistance
    Mortality
    Metaanalysis
    Infection
    Antimicrobial resistance
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ensino
    Engenharias iv
    Engenharias i
    Enfermagem
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Biotecnología
    Biodiversidade
    Astronomia / física
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