Virulence and experimental treatment of Trichoderma longibrachiatum, a fungus refractory to treatment

Author, as appears in the article.: Paredes, Katihuska; Capilla, Javier; Mayayo, Emilio; Guarro, Josep

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel / Paredes Aguilar, Katihuska Viviana

Keywords: Virulence; Trichoderma; Spleen; No poverty; Mycoses; Mice; Micafungin; Male; Liver; Liposomal amphotericin b; Lipopeptides; Echinocandins; Drug combinations; Deoxycholic acid; Antifungal agents; Animals; Amphotericin b, deoxycholate drug combination; Amphotericin b

Abstract: Different inocula of Trichoderma longibrachiatum were tested in a murine model and only the highest one (1 x 107 CFU/animal) killed all the mice at day 15 post infection, being spleen and liver the most affected organs. The efficacy of amphotericin B deoxycholate, liposomal amphotericin B, voriconazole and micafungin was evaluated in the same model with very poor results. Our study demonstrated the low virulence but high resistance to antifungal compounds of this fungus

Thematic Areas: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00664804

Author's mail: javier.capilla@urv.cat

Record's date: 2025-02-18

Paper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://aac.asm.org/content/60/8/5029

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: Antimicrobial Agents And Chemotherapy. 60 (8): 5029-5032

APA: Paredes, Katihuska; Capilla, Javier; Mayayo, Emilio; Guarro, Josep (2016). Virulence and experimental treatment of Trichoderma longibrachiatum, a fungus refractory to treatment. Antimicrobial Agents And Chemotherapy, 60(8), 5029-5032. DOI: 10.1128/AAC.00373-16

Article's DOI: 10.1128/AAC.00373-16

Entity: Universitat Rovira i Virgili

Journal publication year: 2016

Publication Type: Journal Publications