Articles producció científica> Ciències Mèdiques Bàsiques

Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States

  • Identification data

    Identifier: imarina:5130042
    Authors:
    Guevara-Suarez, MarcelaSutton, Deanna ACano-Lira, Jose FGarcia, DaniaMartin-Vicente, AdelaWiederhold, NathanGuarro, JosepGene, Josepa
    Abstract:
    Penicillium species are some of the most common fungi observed worldwide and have an important economic impact as well as being occasional agents of human and animal mycoses. A total of 118 isolates thought to belong to the genus Penicillium based on morphological features were obtained from the Fungus Testing Laboratory at the University of Texas Health Science Center in San Antonio (United States). The isolates were studied phenotypically using standard growth conditions. Molecular identification was made using two genetic markers, the internal transcribed spacer (ITS) and a fragment of the β-tubulin gene. In order to assess phylogenetic relationships, maximum likelihood and Bayesian inference assessments were used. Antifungal susceptibility testing was performed according to CLSI document M38-A2 for nine antifungal drugs. The isolates were identified within three genera, i.e., Penicillium, Talaromyces, and Rasamsonia The most frequent species in our study were Penicillium rubens, P. citrinum, and Talaromyces amestolkiae The potent in vitro activity of amphotericin B (AMB) and terbinafine (TRB) and of the echinocandins against Penicillium and Talaromyces species might offer a good therapeutic alternative for the treatment of infections caused by these fungi.
  • Others:

    Author, as appears in the article.: Guevara-Suarez, Marcela; Sutton, Deanna A; Cano-Lira, Jose F; Garcia, Dania; Martin-Vicente, Adela; Wiederhold, Nathan; Guarro, Josep; Gene, Josepa
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Cano Lira, José Francisco / García Sánchez, Dania / Gené Díaz, Josepa / Guarro Artigas, Josep
    Keywords: Penicillium Molecular phylogeny Fungal identification
    Abstract: Penicillium species are some of the most common fungi observed worldwide and have an important economic impact as well as being occasional agents of human and animal mycoses. A total of 118 isolates thought to belong to the genus Penicillium based on morphological features were obtained from the Fungus Testing Laboratory at the University of Texas Health Science Center in San Antonio (United States). The isolates were studied phenotypically using standard growth conditions. Molecular identification was made using two genetic markers, the internal transcribed spacer (ITS) and a fragment of the β-tubulin gene. In order to assess phylogenetic relationships, maximum likelihood and Bayesian inference assessments were used. Antifungal susceptibility testing was performed according to CLSI document M38-A2 for nine antifungal drugs. The isolates were identified within three genera, i.e., Penicillium, Talaromyces, and Rasamsonia The most frequent species in our study were Penicillium rubens, P. citrinum, and Talaromyces amestolkiae The potent in vitro activity of amphotericin B (AMB) and terbinafine (TRB) and of the echinocandins against Penicillium and Talaromyces species might offer a good therapeutic alternative for the treatment of infections caused by these fungi.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Ciência da computação Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00951137
    Author's mail: dania.garcias@urv.cat josepa.gene@urv.cat jose.cano@urv.cat
    Author identifier: 0000-0003-2397-1646 0000-0001-6195-9299 0000-0003-4495-4394
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://jcm.asm.org/content/54/8/2155
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Clinical Microbiology. 54 (8): 2155-2161
    APA: Guevara-Suarez, Marcela; Sutton, Deanna A; Cano-Lira, Jose F; Garcia, Dania; Martin-Vicente, Adela; Wiederhold, Nathan; Guarro, Josep; Gene, Josepa (2016). Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States. Journal Of Clinical Microbiology, 54(8), 2155-2161. DOI: 10.1128/JCM.00960-16
    Article's DOI: 10.1128/JCM.00960-16
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Microbiology,Microbiology (Medical)
    Penicillium
    Molecular phylogeny
    Fungal identification
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Microbiology (medical)
    Microbiology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Farmacia
    Ensino
    Engenharias ii
    Enfermagem
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
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