Author, as appears in the article.: Simpson, Joanne; Castagno, Davide; Doughty, Rob N.; Poppe, Katrina K.; Earle, Nikki; Squire, Iain; Richards, Mark; Andersson, Bert; Ezekowitz, Justin A.; Komajda, Michel; Petrie, Mark C.; McAlister, Finlay A.; Gamble, Greg D.; Whalley, Gillian A.; McMurray, John J. V.;Meta-Anal Global Grp Chronic Heart
Department: Medicina i Cirurgia
URV's Author/s: Bardají Ruiz, Alfredo
Keywords: Ventricular systolic dysfunction Survival Strict rate control Prognosis Preserved ejection fraction Natriuretic peptide Mortality Morbidity Heart rate Heart failure Follow-up European-society Ejection fraction Beta-blockers Atrial fibrillation preserved ejection fraction heart rate heart failure atrial fibrillation
Abstract: To investigate the relationship between heart rate and survival in patients with heart failure (HF) and coexisting atrial fibrillation (AF).Patients with AF included in the Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) meta-analysis were the main focus of this analysis (3259 patients from 17 studies). The outcome was all-cause mortality at 3 years. Heart rate was analysed as a categorical (tertiles; T1 ?77 b.p.m., T2 78-98 b.p.m., T3 ?98 b.p.m.) and continuous variable. Cox proportional hazard models were used to compare the risk of all-cause death between tertiles of baseline heart rate. Patients in the highest tertile were more often female, less likely to have an ischaemic aetiology or diabetes, had a lower ejection fraction but higher blood pressure and New York Heart Association (NYHA) class. Higher heart rate was associated with higher mortality in patients with sinus rhythm (SR) but not in those in AF. In patients with heart failure and reduced ejection fraction (HF-REF) and AF, death rates per 100 patient years were lowest in the highest heart rate tertile (T1 18.9 vs. T3 15.9) but this difference was not statistically significant (P = 0.10). In patients with heart failure and preserved ejection fraction (HF-PEF), death rates per 100 patient years were highest in the highest heart rate tertile (T1 14.6 vs. T3 16.0, P = 0.014). However, after adjustment for other important prognostic variables, higher heart rate was no longer associated with higher mortality in HF-PEF (or HF-REF).In this meta-analysis of patients with HF, heart rate does not have the same prognostic significance in patients in AF as it does in those in SR, irrespective of ejection fraction or treatment with beta-blocker.© 2015 The Authors European Journal of Heart Failure © 2015 European Society of Cardiology.
Thematic Areas: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Enfermagem Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: alfredo.bardaji@urv.cat
Author identifier: 0000-0003-1900-6974
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1093/eurjhf/hft101
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Journal Of Heart Failure. 17 (11): 1182-1191
APA: Simpson, Joanne; Castagno, Davide; Doughty, Rob N.; Poppe, Katrina K.; Earle, Nikki; Squire, Iain; Richards, Mark; Andersson, Bert; Ezekowitz, Justin (2015). Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation? Results from the MAGGIC meta-analysis. European Journal Of Heart Failure, 17(11), 1182-1191. DOI: 10.1002/ejhf.346
Article's DOI: 10.1002/ejhf.346
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV