Articles producció científicaMedicina i Cirurgia

Targeted metabolomic approach in men with carotid plaque

  • Identification data

    Identifier:  imarina:5132276
    Handle: https://hdl.handle.net/20.500.11797/imarina5132276
    Authors:  Auguet, Teresa; Aragones, Gemma; Colom, Marina; Aguilar, Carmen; Martin-Paredero, Vicente; Canela, Nuria; Ruyra, Xavier; Richart, Cristobal
    Abstract:
    The aim of the study was to analyse the presence of several metabolites related to atherosclerosis in the plasma of patients with unstable carotid plaque and in the plasma of healthy subjects. Materials and methods We included 20 patients who had undergone carotid endarterectomy and 20 healthy subjects as a control group. All the subjects recruited were male. We used a metabolomic approach with liquid chromatography coupled to mass spectrometry to evaluate plasma metabolite levels in the metabolic pathway involved in the progression of atherosclerotic plaque. Results We observed that circulating levels of 20-HETE were significantly higher in patients with atheroma plaque than in healthy subjects (p = 0.018). No differences were found with regard to the other metabolites analysed. We also conducted a random forest analysis and found that 20-HETE was the main differentiator in the list of selected metabolites. In addition, plasma levels of 20-HETE correlated positively with body mass index (r = 0.427, p = 0.007) and diastolic blood pressure (r = 0.365, p = 0.028). Conclusion This study confirms that of all the molecules studied only 20-HETE is related to carotid plaque. Further studies are needed to compare patients with stable carotid plaque vs. patients with unstable carotid plaque in order to confirm that 20-HETE could be a potential factor related to carotid plaque.

  • Others:

    Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200547
    APA: Auguet, Teresa; Aragones, Gemma; Colom, Marina; Aguilar, Carmen; Martin-Paredero, Vicente; Canela, Nuria; Ruyra, Xavier; Richart, Cristobal (2018). Targeted metabolomic approach in men with carotid plaque. Plos One, 13(7), e0200547-e0200547. DOI: 10.1371/journal.pone.0200547
    Paper original source: Plos One. 13 (7): e0200547-e0200547
    Article's DOI: 10.1371/journal.pone.0200547
    Journal publication year: 2018
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2025-03-03
    URV's Author/s: Aguilar Crespillo, Carmen Isabel / ARAGONÈS BARGALLÓ, GEMMA / Auguet Quintillà, Maria Teresa / Martín Paredero, Vicente / Richart Jurado, Cristobal Manuel
    Department: Medicina i Cirurgia
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    ISSN: 19326203
    Author, as appears in the article.: Auguet, Teresa; Aragones, Gemma; Colom, Marina; Aguilar, Carmen; Martin-Paredero, Vicente; Canela, Nuria; Ruyra, Xavier; Richart, Cristobal
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Zootecnia / recursos pesqueiros, Sociology, Sociología, Serviço social, Saúde coletiva, Química, Psychology, Psicología, Planejamento urbano e regional / demografia, Odontología, Nutrição, Multidisciplinary sciences, Multidisciplinary, Medicine (miscellaneous), Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Materiais, Matemática / probabilidade e estatística, Linguística e literatura, Letras / linguística, Interdisciplinary research in the social sciences, Interdisciplinar, Human geography and urban studies, History & philosophy of science, Historia, Geografía, Geociências, General medicine, General biochemistry,genetics and molecular biology, General agricultural and biological sciences, Farmacia, Environmental studies, Ensino, Engenharias iv, Engenharias iii, Engenharias ii, Engenharias i, Enfermagem, Educação física, Educação, Economia, Direito, Demography, Comunicação e informação, Ciências sociais aplicadas i, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Ciência política e relações internacionais, Ciência de alimentos, Ciência da computação, Biotecnología, Biology, Biodiversidade, Biochemistry, genetics and molecular biology (miscellaneous), Astronomia / física, Arquitetura, urbanismo e design, Archaeology, Antropologia / arqueologia, Anthropology, Agricultural and biological sciences (miscellaneous), Administração, ciências contábeis e turismo, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: cristobalmanuel.richart@urv.cat, carmenisabel.aguilar@urv.cat, carmenisabel.aguilar@urv.cat, mariateresa.auguet@urv.cat

  • Keywords:

    Plaque
    atherosclerotic
    Middle aged
    Metabolomics
    Mass spectrometry
    Male
    Life on land
    Hydroxyeicosatetraenoic acids
    Humans
    Endarterectomy
    carotid
    Carotid artery diseases
    Aged
    20-hydroxy-5
    14-eicosatetraenoic acid
    Agricultural and Biological Sciences (Miscellaneous)
    Biochemistry
    Genetics and Molecular Biology (Miscellaneous)
    Biology
    Medicine (Miscellaneous)
    Multidisciplinary
    Multidisciplinary Sciences
    Zootecnia / recursos pesqueiros
    Sociology
    Sociología
    Serviço social
    Saúde coletiva
    Química
    Psychology
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinary research in the social sciences
    Interdisciplinar
    Human geography and urban studies
    History & philosophy of science
    Historia
    Geografía
    Geociências
    General medicine
    General biochemistry
    genetics and molecular biology
    General agricultural and biological sciences
    Farmacia
    Environmental studies
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Economia
    Direito
    Demography
    Comunicação e informação
    Ciências sociais aplicadas i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência política e relações internacionais
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Arquitetura
    urbanismo e design
    Archaeology
    Antropologia / arqueologia
    Anthropology
    Administração
    ciências contábeis e turismo
    Ad

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