Author, as appears in the article.: Guaita-Esteruelas S., Saavedra-García P., Bosquet A., Borràs J., Girona J., Amiliano K., Rodríguez-Balada M., Heras M., Masana L., Gumà J.
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: BORRAS BALADA, JOAN LLUÍS / BOSQUET AGUDO, ALBA / Girona Tell, Josefa / GUAITA ESTERUELAS, SANDRA / HERAS IBAÑEZ, MERCEDES / Masana Marín, Luis / RODRÍGUEZ BALADA, MARTA
Keywords: Risk Retinoic-acid Resistance Obesity Lipid metabolism Lipid chaperones Growth Expression Breast cancer Biomarkers Atherogenic dyslipidemia Association Adipokines lipid chaperones breast cancer adipokines
Abstract: Background. Adipose tissue is an endocrine organ that could play a role in tumor progression via its secreted adipokines. The role of adipose-derived fatty acid-binding protein (FABP) 4 and FABP5 in breast cancer is presently under study, but their circulating levels in this pathology are poorly known. We analyzed the blood concentrations of FABP4 and FABP5 in breast cancer patients to determine whether there is an association between them and breast cancer.
Materials and Methods. We studied 294 women in the oncology department with a family history of breast cancer; 198 of the women had breast cancer, and 96 were healthy controls. The levels of FABP4, FABP5, lipid profile, standard biochemical parameter, and high-sensitivity C-reactive protein (hsCRP) were determined. We analyzed the association of FABP4 and FABP5 with breast cancer, while adjusting for demographic, anthropometric, and biochemical parameters.
Results. Breast cancer patients had a 24.8% (p < .0001) and 11.4% (p < .05) higher blood concentration of FABP4 and FABP5, respectively. Fatty acid-binding protein 4 was positively associated with age, body mass index (BMI), FABP5, very-low-density lipoprotein cholesterol (VLDLc), non-highdensity lipoprote in cholesterol (non-HDLc), Apolipoprotein B 100 (ApoB100), triglycerides, glycerol, glucose, and hsCRP (p < .05), and was negatively associated with HDLc (p < .005) in breast cancer patients. Fatty acid-binding protein 5 was positively associated with BMI, FABP4, VLDLc, triglycerides, glycerol, and hsCRP (p < .05), and was negatively associated with HDLc and Apolipoprotein AI (ApoAI) (p < .05) in breast cancer patients. Using a logistic regression analysis and adjusting for age, BMI, hsCRP, non-HDLc, and triglycerides, FABP4 was independently associated with breast cancer (odds ratio [OR]: 1.091 [95% CI: 1.037-1.149]). Moreover, total cholesterol, VLDLc, non-HDLc, ApoB100, triglycerides, and hsCRP were significantly increased in breast cancer patients (p < .005). In contrast, the non-esterified fatty acids concentrations were significantly decreased in breast cancer patients (p < .05).
Conclusion. Circulating FABP4 and FABP5 levels were increased in breast cancer patients compared with controls. The positive association of FABP4 with breast cancer was maintained after adjusting for important covariates, while the association with FABP5 was lost. Our data reinforce the role of adipose tissue and their adipokines in breast cancer. Despite these data, further studies must be performed to better explain the prognosis or diagnostic value of these blood parameters and their possible role in breast cancer.
Thematic Areas: Oncology Medicine (miscellaneous) Medicine (all) Medicina i Farmacia Enfermagem Ciências biológicas ii Cancer research Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 10837159
Author's mail: josefa.girona@urv.cat josefa.girona@urv.cat luis.masana@urv.cat
Author identifier: 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-0789-4954
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://theoncologist.onlinelibrary.wiley.com/doi/full/10.1634/theoncologist.2016-0483
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Oncologist. 22 (11): 1309-1315
APA: Guaita-Esteruelas S., Saavedra-García P., Bosquet A., Borràs J., Girona J., Amiliano K., Rodríguez-Balada M., Heras M., Masana L., Gumà J. (2017). Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients. Oncologist, 22(11), 1309-1315. DOI: 10.1634/theoncologist.2016-0483
Article's DOI: 10.1634/theoncologist.2016-0483
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV