Author, as appears in the article.: Pedret, Anna; Valls, Rosa M; Calderon-Perez, Lorena; Llaurado, Elisabet; Companys, Judit; Pla-Paga, Laura; Moragas, Ana; Martin-Lujan, Francisco; Ortega, Yolanda; Giralt, Montse; Caimari, Antoni; Chenoll, Empar; Genoves, Salvador; Martore, Patricia; Codoner, Francisco M; Ramon, Daniel; Arola, Lluis; Sola, Rosa
Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia Medicina i Cirurgia
URV's Author/s: Arola Ferrer, Luis Maria / Calderon Pérez, Lorena / Companys Alemany, Judit / Giralt Batista, Montserrat / Llauradó Ribé, Elisabet / Martín Lujan, Francisco Manuel / Moragas Fernández, Albert / Ortega Vila, Yolanda / Pedret Figuerola, Anna / PLA PAGA, LAURA / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: Waist circumference Tissue Probiotics Overweight Obesity, abdominal Nutrition Metaanalysis Mass Male Lactobacillus-gasseri sbt2055 Index Humans Female Diet Clinical trial Cardiovascular risk Bifidobacterium animalis Adults Adult Adiposity Abdominal obesity
Abstract: © 2018, The Author(s). Background: The effects of probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (Ba8145) and those of its heat-killed form (h-k Ba8145) on human anthropometric adiposity biomarkers are unknown. Objective: To assess the effect of Ba8145 and h-k Ba8145 ingestion on anthropometric adiposity biomarkers. Design: Randomized, parallel, double-blind, placebo-controlled trial with abdominally obese individuals. Participants (n = 135) consumed 1 capsule/day containing 1010 colony forming unit (CFU) of Ba8145, 1010 CFU of h-k Ba8145, or placebo (maltodextrin) for 3 months. Results: Ba8145 ingestion decreased waist circumference, waist circumference/height ratio, and Conicity index (P < 0.05) versus its baseline. Changes versus the placebo group reached significance (P < 0.05) after the h-k Ba8145 treatment. Ba8145 decreased the body mass index compared with baseline and placebo group (P < 0.05). The decrease in visceral fat area after Ba8145 treatments reached significance (P < 0.05) only after h-k Ba8145. When analyses by gender were performed, significance remained only for women. Diastolic blood pressure and HOMA index decreased (P < 0.05) after h-k Ba8145. Gut microbiome analyses showed an increase in Akkermansia spp. after Ba8145 treatment, particularly in the live form, which was inversely related to weight (P = 0.003). Conclusions: In abdominally obese individuals, consumption of Ba8145, both as viable and mainly as heat-killed cells, improves anthropometric adiposity biomarkers, particularly in women. An increase in the gut Akkermansia genus appears as a possible mechanism involved. Our results support Ba8145 probiotic as a complementary strategy in obesity management.
Thematic Areas: Serviço social Saúde coletiva Psicología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03070565
Author's mail: yolanda.ortega@urv.cat judit.companys@urv.cat lorena.calderon@urv.cat anna.pedret@urv.cat albert.moragas@urv.cat elisabet.llaurado@urv.cat albert.moragas@urv.cat montse.giralt@urv.cat judit.companys@urv.cat judit.companys@urv.cat paco.martin@urv.cat lorena.calderon@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Author identifier: 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-5327-932X 0000-0002-7439-9531 0000-0002-7073-577X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0003-0359-3588 0000-0003-0766-0733 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
Last page: 1868
Record's date: 2024-10-19
Journal volume: 43
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41366-018-0220-0
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Obesity. 43 (9): 1863-1868
APA: Pedret, Anna; Valls, Rosa M; Calderon-Perez, Lorena; Llaurado, Elisabet; Companys, Judit; Pla-Paga, Laura; Moragas, Ana; Martin-Lujan, Francisco; Orte (2019). Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. International Journal Of Obesity, 43(9), 1863-1868. DOI: 10.1038/s41366-018-0220-0
Article's DOI: 10.1038/s41366-018-0220-0
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
First page: 1863
Publication Type: Journal Publications
Repositori URV