Articles producció científica> Medicina i Cirurgia

Survivin is a negative prognostic factor in malignant pleural effusion

  • Identification data

    Identifier: imarina:5651850
    Authors:
    Arellano-Orden ERomero-Romero BSánchez-López VMartín-Juan JRodríguez-Panadero FOtero-Candelera R
    Abstract:
    © 2018 Stichting European Society for Clinical Investigation Journal Foundation Background: Survivin is a well-known member of the inhibitor of apoptosis family, and has been related to increased tumour aggressivity, both in tissue and in pleural fluid. Objectives: In patients with malignant pleural effusion, we sought to investigate the changes in pleural fluid survivin concentrations induced by talc instillation into the pleural space. Those changes were also examined in relation to pleurodesis outcome and patient survival. Methods: We investigated 84 patients with malignant pleural effusion who underwent talc pleurodesis. Of them, 32 had breast cancer, 25 lung cancer and 27 had mesothelioma. Serial samples of pleural fluid were obtained before thoracoscopy (baseline) and 24 hours thereafter. Results: Survivin levels were successfully quantified in all pleural fluid samples, and they were significantly higher in samples obtained after thoracoscopic talc poudrage compared with baseline (P <.001). Patients with higher pleural fluid survivin levels at baseline had a significantly poorer pleurodesis outcome (P =.004). A 30 pg/mL cut-off for baseline survivin in pleural fluid predicted failure of pleurodesis with a 54% sensitivity and 79% specificity (P =.009). Moreover, median postpleurodesis survival of patients with baseline survivin levels ≥30 pg/mL was 4 months (range: 0.1-38), compared with 13 months (range: 0.1-259) in patients below that cut-off (P <.001). Conclusion: Elevated pleural fluid survivin concentrations are useful to predict failure of pleurodesis and are associated with shorter survival in patients with malignant pleural effusion.
  • Others:

    Author, as appears in the article.: Arellano-Orden E; Romero-Romero B; Sánchez-López V; Martín-Juan J; Rodríguez-Panadero F; Otero-Candelera R
    Department: Medicina i Cirurgia
    URV's Author/s: Porras Ledantes, Jose Antonio
    Keywords: Talc pleurodesis Survivin Survival Pleurodesis Metaanalysis Mesothelioma cells Malignant pleural effusion Lung-cancer Induction Expression Diagnostic-value Bcl-2 Apoptosis survival pleurodesis malignant pleural effusion
    Abstract: © 2018 Stichting European Society for Clinical Investigation Journal Foundation Background: Survivin is a well-known member of the inhibitor of apoptosis family, and has been related to increased tumour aggressivity, both in tissue and in pleural fluid. Objectives: In patients with malignant pleural effusion, we sought to investigate the changes in pleural fluid survivin concentrations induced by talc instillation into the pleural space. Those changes were also examined in relation to pleurodesis outcome and patient survival. Methods: We investigated 84 patients with malignant pleural effusion who underwent talc pleurodesis. Of them, 32 had breast cancer, 25 lung cancer and 27 had mesothelioma. Serial samples of pleural fluid were obtained before thoracoscopy (baseline) and 24 hours thereafter. Results: Survivin levels were successfully quantified in all pleural fluid samples, and they were significantly higher in samples obtained after thoracoscopic talc poudrage compared with baseline (P <.001). Patients with higher pleural fluid survivin levels at baseline had a significantly poorer pleurodesis outcome (P =.004). A 30 pg/mL cut-off for baseline survivin in pleural fluid predicted failure of pleurodesis with a 54% sensitivity and 79% specificity (P =.009). Moreover, median postpleurodesis survival of patients with baseline survivin levels ≥30 pg/mL was 4 months (range: 0.1-38), compared with 13 months (range: 0.1-259) in patients below that cut-off (P <.001). Conclusion: Elevated pleural fluid survivin concentrations are useful to predict failure of pleurodesis and are associated with shorter survival in patients with malignant pleural effusion.
    Thematic Areas: Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00142972
    Author's mail: joseantonio.porras@urv.cat
    Author identifier: 0000-0001-6418-1822
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12895
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: European Journal Of Clinical Investigation. 48 (4):
    APA: Arellano-Orden E; Romero-Romero B; Sánchez-López V; Martín-Juan J; Rodríguez-Panadero F; Otero-Candelera R (2018). Survivin is a negative prognostic factor in malignant pleural effusion. European Journal Of Clinical Investigation, 48(4), -. DOI: 10.1111/eci.12895
    Article's DOI: 10.1111/eci.12895
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Clinical Biochemistry,Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental
    Talc pleurodesis
    Survivin
    Survival
    Pleurodesis
    Metaanalysis
    Mesothelioma cells
    Malignant pleural effusion
    Lung-cancer
    Induction
    Expression
    Diagnostic-value
    Bcl-2
    Apoptosis
    survival
    pleurodesis
    malignant pleural effusion
    Saúde coletiva
    Odontología
    Nutrição
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry
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