Author, as appears in the article.: Taverner, D; Paredes, S; Ferré, R; Masana, L; Castro, A; Vallvé, JC
Department: Medicina i Cirurgia
URV's Author/s: Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / Masana Marín, Luis / Paredes Gonzalez-Albo, Silvia Remedios / Vallvé Torrente, Joan Carles
Keywords: Systemic-lupus-erythematosus Risk-factors Reference values Pulse-wave velocity Noninvasive assessment Hemodynamics Determinants Cardiovascular-disease Blood-pressure Atherosclerosis
Abstract: We aimed to study arterial stiffness variables in patients with rheumatoid arthritis (RA), specifically considering their associations with path model mediation analysis. We examined arterial stiffness expressed by the pulse wave velocity (PVW), augmentation index (AIx), distensibility, and clinical and biochemical characteristics in a cohort of 214 RA patients. Variable associations were analysed using multivariate linear regression analysis. We also used path model mediation analysis for PWV variable. Our results indicate that age, systolic blood pressure (SBP), and body mass index (BMI) were significantly associated with PWV, and collectively accounted for 32% of PWV variability. The parallel mediation analysis showed that SBP and BMI accounted for 21% and 7% (a total of 28%) of the total effect of age on PWV, respectively, indicating a partial mediation effect. The associated variables with AIx were age and tender joint count, while those with distensibility were BMI and sex, overall accounting for 16.5% and 4.7% of the variation in AIx and distensibility, respectively. We observed no associations of arterial stiffness with inflammatory variables, disease activity and duration, or cholesterol levels. In conclusion, in our population of RA patients, age is the most important variable that determines the increase in PWV. We have also shown that a significant proportion of the negative effects of age on PWV occurs through increases in SBP and BMI. In our study, lipid and inflammation variables were not associated with an increase in arterial stiffness.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Author's mail: silviaremedios.paredes@urv.cat jc.vallve@urv.cat luis.masana@urv.cat antoni.castro@urv.cat jc.vallve@urv.cat
Author identifier: 0000-0002-0789-4954 0000-0001-5441-6333
Record's date: 2024-01-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41598-019-41069-5
Papper original source: Scientific Reports. 9 (1): 4543-4543
APA: Taverner, D; Paredes, S; Ferré, R; Masana, L; Castro, A; Vallvé, JC (2019). Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis.. Scientific Reports, 9(1), 4543-4543. DOI: 10.1038/s41598-019-41069-5
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1038/s41598-019-41069-5
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications