Articles producció científica> Medicina i Cirurgia

Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis.

  • Identification data

    Identifier: imarina:5671184
    Authors:
    Taverner, DParedes, SFerré, RMasana, LCastro, AVallvé, JC
    Abstract:
    We aimed to study arterial stiffness variables in patients with rheumatoid arthritis (RA), specifically considering their associations with path model mediation analysis. We examined arterial stiffness expressed by the pulse wave velocity (PVW), augmentation index (AIx), distensibility, and clinical and biochemical characteristics in a cohort of 214 RA patients. Variable associations were analysed using multivariate linear regression analysis. We also used path model mediation analysis for PWV variable. Our results indicate that age, systolic blood pressure (SBP), and body mass index (BMI) were significantly associated with PWV, and collectively accounted for 32% of PWV variability. The parallel mediation analysis showed that SBP and BMI accounted for 21% and 7% (a total of 28%) of the total effect of age on PWV, respectively, indicating a partial mediation effect. The associated variables with AIx were age and tender joint count, while those with distensibility were BMI and sex, overall accounting for 16.5% and 4.7% of the variation in AIx and distensibility, respectively. We observed no associations of arterial stiffness with inflammatory variables, disease activity and duration, or cholesterol levels. In conclusion, in our population of RA patients, age is the most important variable that determines the increase in PWV. We have also shown that a significant proportion of the negative effects of age on PWV occurs through increases in SBP and BMI. In our study, lipid and inflammation variables were not associated with an increase in arterial stiffness.
  • Others:

    Author, as appears in the article.: Taverner, D; Paredes, S; Ferré, R; Masana, L; Castro, A; Vallvé, JC
    Department: Medicina i Cirurgia
    URV's Author/s: Castro Salomó, Antoni / FERRÉ VALLÈS, RAIMON / Masana Marín, Luis / Paredes Gonzalez-Albo, Silvia Remedios / Vallvé Torrente, Joan Carles
    Keywords: Systemic-lupus-erythematosus Risk-factors Reference values Pulse-wave velocity Noninvasive assessment Hemodynamics Determinants Cardiovascular-disease Blood-pressure Atherosclerosis
    Abstract: We aimed to study arterial stiffness variables in patients with rheumatoid arthritis (RA), specifically considering their associations with path model mediation analysis. We examined arterial stiffness expressed by the pulse wave velocity (PVW), augmentation index (AIx), distensibility, and clinical and biochemical characteristics in a cohort of 214 RA patients. Variable associations were analysed using multivariate linear regression analysis. We also used path model mediation analysis for PWV variable. Our results indicate that age, systolic blood pressure (SBP), and body mass index (BMI) were significantly associated with PWV, and collectively accounted for 32% of PWV variability. The parallel mediation analysis showed that SBP and BMI accounted for 21% and 7% (a total of 28%) of the total effect of age on PWV, respectively, indicating a partial mediation effect. The associated variables with AIx were age and tender joint count, while those with distensibility were BMI and sex, overall accounting for 16.5% and 4.7% of the variation in AIx and distensibility, respectively. We observed no associations of arterial stiffness with inflammatory variables, disease activity and duration, or cholesterol levels. In conclusion, in our population of RA patients, age is the most important variable that determines the increase in PWV. We have also shown that a significant proportion of the negative effects of age on PWV occurs through increases in SBP and BMI. In our study, lipid and inflammation variables were not associated with an increase in arterial stiffness.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20452322
    Author's mail: silviaremedios.paredes@urv.cat jc.vallve@urv.cat luis.masana@urv.cat antoni.castro@urv.cat jc.vallve@urv.cat
    Author identifier: 0000-0002-0789-4954 0000-0001-5441-6333
    Record's date: 2024-01-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-019-41069-5
    Papper original source: Scientific Reports. 9 (1): 4543-4543
    APA: Taverner, D; Paredes, S; Ferré, R; Masana, L; Castro, A; Vallvé, JC (2019). Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis.. Scientific Reports, 9(1), 4543-4543. DOI: 10.1038/s41598-019-41069-5
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1038/s41598-019-41069-5
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Systemic-lupus-erythematosus
    Risk-factors
    Reference values
    Pulse-wave velocity
    Noninvasive assessment
    Hemodynamics
    Determinants
    Cardiovascular-disease
    Blood-pressure
    Atherosclerosis
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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