Author, as appears in the article.: Salas, Daniela; Borrull, Francesc; Fontanals, Nuria; Maria Marce, Rosa
Department: Química Analítica i Química Orgànica
URV's Author/s: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria / SALAS ACOSTA, DANIELA
Keywords: Waste-water Transformation products Tandem mass-spectrometry Surface-water Sorbent combination Solid-phase extraction Selective determination Samples Quantification Mixed mode ionic exchange sorbents Liquid chromatography-orbitrap-high resolution mass spectrometry Liquid chromatography Illicit drugs High-resolution mass spectrometry Environmental waters Contaminants Cationic mixed-mode solid-phase extraction Cathinones Anionic mixed-mode solid-phase extraction high-resolution mass spectrometry environmental waters cationic mixed-mode solid-phase extraction anionic mixed-mode solid-phase extraction
Abstract: The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, analytical Biotecnología Biodiversidade Biochemistry Biochemical research methods Astronomia / física Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16182642
Author's mail: nuria.fontanals@urv.cat nuria.fontanals@urv.cat rosamaria.marce@urv.cat francesc.borrull@urv.cat
Author identifier: 0000-0002-7534-1964 0000-0002-7534-1964 0000-0002-5667-2899 0000-0003-2718-9336
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://link.springer.com/article/10.1007/s00216-017-0736-5
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Analytical And Bioanalytical Chemistry. 410 (2): 459-469
APA: Salas, Daniela; Borrull, Francesc; Fontanals, Nuria; Maria Marce, Rosa (2018). Combining cationic and anionic mixed-mode sorbents in a single cartridge to extract basic and acidic pharmaceuticals simultaneously from environmental waters. Analytical And Bioanalytical Chemistry, 410(2), 459-469. DOI: 10.1007/s00216-017-0736-5
Article's DOI: 10.1007/s00216-017-0736-5
Entity: Universitat Rovira i Virgili
Journal publication year: 2018
Publication Type: Journal Publications
Repositori URV