Author, as appears in the article.: Esplugas R; Arenas M; Serra N; Bellés M; Bonet M; Gascón M; Vallvé J; Linares V
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Arenas Prat, Meritxell / Bellés Mateu, Montserrat / Esplugas Borràs, Roser / Linares Vidal, M. Victoria / Serra Encinas, Noemi / Vallvé Torrente, Joan Carles
Keywords: Suppression Rnas Risk Radiotherapy Potential biomarker Mirnas plasmáticos Mir-221/222 Mir-146a Coronary-heart-disease Circulating micrornas Breast cancer Artery Altered expression
Abstract: © 2019 Esplugas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Breast cancer (BC) is one of the most important neoplasias among women. Many patients receive radiotherapy (RT), which involves radiation exposure of the thoracic zone, including the heart and blood vessels, leading to the development of cardiovascular disease (CVD) as a long-term side effect. The severity of CVD-related pathologies leads research on assessing novel CVD biomarkers as diagnostic, prognostic or therapeutic agents. Currently, the possible candidates include blood microRNAs (miRNAs). Previous studies have supported a role for miRNA-146a, -155, -221, and -222 in the progression of CVD. Our purpose was to evaluate the RT-induced modulation of the expression of these miRNAs in the blood of women with BC. Pre-RT control and post-RT blood samples were collected, and after miRNA isolation and reverse transcription, the levels of the selected miRNAs were measured by real-time PCR. Our results showed that miRNA-155 exhibited the lowest expression, while miRNA-222 exhibited the highest expression, followed by miRNA-221. The expression of each individual miRNA was positively correlated with that of the others both pre-RT control and post-RT and inversely correlated with age before RT. Furthermore, RT promoted the overexpression of the selected miRNAs. Their levels were also affected by CVD-linked clinical parameters, treatment and BC side. Modulation of the expression of the selected miRNAs together with other risk factors might be associated with the development of future cardiovascular pathologies. Further confirmatory studies are needed to assess their potential as possible biomarkers in the progression of or as therapeutic targets for RT-induced CVD in BC patients.
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licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19326203
Author's mail: jc.vallve@urv.cat montserrat.belles@urv.cat jc.vallve@urv.cat mvictoria.linares@urv.cat noemi.serra@urv.cat meritxell.arenas@urv.cat
Author identifier: 0000-0002-9282-2989 0000-0003-4170-4197 0000-0002-2277-351X 0000-0003-0815-2570
Record's date: 2024-06-22
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217443
Papper original source: Plos One. 14 (5): e0217443-
APA: Esplugas R; Arenas M; Serra N; Bellés M; Bonet M; Gascón M; Vallvé J; Linares V (2019). Effect of radiotherapy on the expression of cardiovascular disease-related miRNA-146a, -155, -221 and -222 in blood of women with breast cancer. Plos One, 14(5), e0217443-. DOI: 10.1371/journal.pone.0217443
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1371/journal.pone.0217443
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV