Author, as appears in the article.: Reyes C; Pons N; Reñones C; Gallisà J; Val V; Tebé C; Mateo G
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Aranda Pons, Núria / Arija Val, Maria Victoria / Basora Gallisa, Josep / Flores Mateo, Gemma / TEBÉ CORDOMÍ, CRISTIAN
Keywords: Vascular-diseases Risk-factor Myocardial-infarction Incidence Hemoglobin Ferritin Coronary heart disease Cardiovascular-disease Body iron stores ferritin coronary heart disease
Abstract: © 2019 Elsevier B.V. Background and aims: Several studies aiming to determine the association between iron stores and coronary heart disease (CHD) have reported conflicting results. None of them has been performed in a Mediterranean region. Our aim is to assess the association between the level of serum ferritin and the incidence of CHD in a Mediterranean region. Methods: We performed a cohort study using a primary health care population database. Primary outcome was incidence of CHD. Subjects aged between 35 and 74 years with serum ferritin (SF) measurements at baseline (January 1, 2006 to December 31, 2008) were included. Cox regression models were used to compute hazard ratios (HRs) and 95%CIs for the associtation between SF and time until CHD outcome. Results: We include 242,084 subjects with SF levels at baseline. Participants were observed for a median of 8.4 years. During follow-up, 1106 incident cases of CHD were identified. Persons with elevated SF did not have an increased CHD risk at follow-up (adjusted hazard ratio = 0.99; 95%CI 0.94–1.05; p = 0.86 in men, and 0.95; 95%CI 0.81–1.13; p = 0.60 in women). Conclusions: Our study, by far the largest, showed that high levels of SF do not confer an increased risk of CHD, and questions its role as a risk factor for this disease.
Thematic Areas: Saúde coletiva Psicología Peripheral vascular disease Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00219150
Author's mail: gemma.flores@urv.cat josep.basora@urv.cat nuria.aranda@urv.cat victoria.arija@urv.cat josep.basora@urv.cat
Author identifier: 0000-0001-9708-747X 0000-0002-1758-0975
Record's date: 2024-05-11
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.atherosclerosis-journal.com/article/S0021-9150(19)31629-6/abstract#%20
Papper original source: Atherosclerosis. 293 69-74
APA: Reyes C; Pons N; Reñones C; Gallisà J; Val V; Tebé C; Mateo G (2020). Association between serum ferritin and acute coronary heart disease: A population-based cohort study. Atherosclerosis, 293(), 69-74. DOI: 10.1016/j.atherosclerosis.2019.12.011
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.atherosclerosis.2019.12.011
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV