Author, as appears in the article.: Llaurado, Gemma; Amigo, Nuria; Cano, Albert; Ballesta, Silvia; Albert, Lara; Mazarico, Isabel; Fernandez-Veledo, Sonia; Pedro-Botet, Juan; Vendrell, Joan; Gonzalez-Clemente, Jose-Miguel
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Fernandez Veledo, Sonia / Vendrell Ortega, Juan José
Keywords: Type 1 diabetes mellitus; Scientific statement; Preclinical atherosclerosis; Pittsburgh epidemiology; Nuclear magnetic resonance spectroscopy; Metabolic syndrome; Low-density-lipoprotein; Lipoprotein subclass profiles; Ldl particle number; Insulin-resistance; Excess mortality; Division working group; Cardiovascular-disease; Cardiovascular risk; Arterial stiffness; All-cause mortality; preclinical atherosclerosis; nuclear magnetic resonance spectroscopy; lipoprotein subclass profiles; cardiovascular risk; arterial stiffness
Abstract: Background: Dyslipidemia has been associated with vascular complications of type 1 diabetes mellitus (T1DM). We examined the proton nuclear magnetic resonance (NMR)-assessed lipoprotein subclass profiles in subjects with T1DM compared with those of healthy subjects and assessed the potential relationship of these profiles with arterial stiffness. Methods: Eighty-four participants with T1DM of at least 10 years duration and no clinical cardiovascular disease (age: 35-65 years; 50% men) and 42 healthy participants were evaluated for: (1) clinical and anthropometric data (including classical cardiovascular risk factors), (2) insulin sensitivity by estimated glucose disposal rate, (3) microvascular complications, (4) NMR-assessed lipoprotein subclass profile, and (5) arterial stiffness (aortic pulse wave velocity). Results: Participants with T1DM had an apparently better conventional lipid profile than healthy participants, but with significant differences in NMR-assessed lipoprotein profiles such as higher triglyceride content of low-density lipoprotein (LDL) and high-density lipoprotein (HDL). In healthy participants, arterial stiffness was associated with NMR-based LDL subclasses. By contrast, in T1DM participants, arterial stiffness was independently associated mainly with NMR-based very-low-density lipoprotein (VLDL) subclasses: positively with total VLDL particles (and subclasses) and VLDL triglyceride content, and negatively with LDL and HDL particle sizes. These results were maintained after adjustments for classical cardiovascular risk factors. Conclusions: Subjects with T1DM, while having an apparently better conventional lipid profile than healthy controls, presented significant alterations in their NMR-assessed lipoprotein profile. The association between arterial stiffness and NMR-assessed lipoprotein profiles also differed in both groups. These results support a potential role of the identified differences in the residual cardiovascular risk in T1DM.
Thematic Areas: Medicine, general & internal; Medicine (miscellaneous); Medicine (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20770383
Author's mail: sonia.fernandez@urv.cat; jvortega@iispv.cat
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2077-0383/8/11/1875
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Journal Of Clinical Medicine. 8 (11): 1875-
APA: Llaurado, Gemma; Amigo, Nuria; Cano, Albert; Ballesta, Silvia; Albert, Lara; Mazarico, Isabel; Fernandez-Veledo, Sonia; Pedro-Botet, Juan; Vendrell, J (2019). Specific Nuclear Magnetic Resonance Lipoprotein Subclass Profiles and Central Arterial Stiffness in Type 1 Diabetes Mellitus: A Case Control Study. Journal Of Clinical Medicine, 8(11), 1875-. DOI: 10.3390/jcm8111875
Article's DOI: 10.3390/jcm8111875
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV